Table 2

The profile of proinflammatory cytokine and chemokine secretion of mDCs in response to C. parapsilosis

mDC (24 h)


(pg/ml)

unstimulated

Cp wt

Cp lip-/-


IL-1 α

21.90(6.64- 70.46)

241.71 (19.78- 366.12)

487.97# (110.80- 548.77)

IL-6

159.26 (38.75- 226.87)

3934.41 (2481.7-6316.06)

6535.23# (3122.14-9215.14)

TNF α

99.51 (58.12-158.89)

1724.67 (736.08-2859.76)

3454.13# (2934.29-4139.50)

CXCL8

1632.81 (1358.45-2897.26)

3420.32 (3268-6563.96)

2657.64 (1846.33-3076.52)


mDC (48 h)


(pg/ml)

unstimulated

Cp wt

Cp lip-/-


IL-1 α

22.97 (11.17-40.30)

35.58 (11.19-68.98)

126.87# (59.90-198.21)

IL-6

4364.11 (4025.97-5410.58)

5873.19 (4767.13-7510.32)

7988.22# (6119.10-9893.27)

TNF α

124.92 (74.93-163.21)

3456.54 (1628.19-5686.98)

4345.39 (2694.78-5426.10)

CXCL8

2223.11 (898.14-4978.58)

2605.43 (1254.21-5297.94)

2392.44 (1226.74-5394.56)


n = 8 independent blood donors

Mature dendritic cells were stimulated with C. parapsilosis wild type (Cp wt), lipase deficient (Cp lip-/-) cells or left unstimulated. Secretion of IL-1α, IL-6, TNF-α or CXCL8 by iDCs was determined by Luminex analyzer or ELISA at 24 h and 48 h post-infection. †: medians (interquartile ranges) # p < 0.05

Nagy et al. BMC Microbiology 2011 11:122   doi:10.1186/1471-2180-11-122

Open Data