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Open Access Highly Accessed Research article

Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis

Nichole A Broderick1234, Kenneth F Raffa1 and Jo Handelsman235*

Author Affiliations

1 Department of Entomology, University of Wisconsin, Madison, WI 53706, USA

2 Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA

3 Department of Plant Pathology University of Wisconsin, Madison, WI 53706, USA

4 Current address: Global Health Institute, EPFL, Lausanne, 1004, Switzerland

5 Current address: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA

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BMC Microbiology 2010, 10:129  doi:10.1186/1471-2180-10-129

Published: 27 April 2010

Additional files

Additional file 1:

Figure S1. Effect of ingestion of B. thuringiensis (DiPel 50 IU) on larval hemocytes at t = 0 h.

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Additional file 2:

Table S1. Summary of the log-rank statistics of survival of third-instar gypsy moth larvae following ingestion of B. thuringiensis toxin and various bacterial cell components.

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Additional file 3:

Table S2. Larval mortality to bacterial cell-derived compounds in the absence of B. thuringiensis.

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Additional file 4:

Table S3. Summary of the log-rank statistics of survival of third-instar gypsy moth larvae following ingestion of B. thuringiensis toxin and various concentrations of three COX inhibitors.

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