Repression or induction of transcription of genes in response to addition of iron and heme. Fold changes in expression of four genes in H. influenzae strain R2846 over the course of 150 minutes of growth under two different growth conditions. Strain R2846 was grown in either: 1) medium that was restricted for iron and heme for the duration of the experiment (black triangles) or 2) medium that was restricted for iron and heme up to 90 minutes at which point iron and heme were added to fully supplement the medium (red circles). Results are shown for r2846.1777 (A), fhuC (B), hxuC (C) and adhC (D).
Morton et al. BMC Microbiology 2010 10:113 doi:10.1186/1471-2180-10-113