Table 1

Differential macrophage gene expression in M. avium 109 and 2D6 mutant

Gene

Gene Bank ID

Name

Function

Fold induction (± SD)

p value <0.05


APBA2

AB014719

Amyloid beta (A4) precursor protein binding

Signal transduction

10.7 ± 2.3

Y

CYP4F2

U02388

Cytochrome P450

Inactivation & degradation of leukotriene B4

2.6 ± 0.9

Y

DGKA

AF064767

Diacylglycerol kinase alpha

Intracellular signaling

2.3 ± 0.4

Y

DGKD

D63479

Diacylglycerol kinase delta

Phosphatidylinositol signaling

6.7 ± 1.2

Y

DYNC1H1

AB002323

Cytosolic dyenin heavy chain

Microtubule reorganization

17.4 ± 3.1

Y

GPD2

NM_000408

Glycerol-3-phosphate dehydrogenase 2

Glycerol-3-phosphate metabolism

3.5 ± 0.4

Y

GRK4

NM_005307

G-protein coupled receptor kinase 4

Regulation of G-protein coupled receptor protein signaling

3.5 ± 0.6

Y

HIPK3

AF004849

Homeodomain interacting protein kinase 3

Inhibition of apoptosis

2.05 ± 0.3

Y

INPP1

NM_002194

Inositol polyphosphate-1-phosphatase

Phosphatidylinositol signaling

2.0 ± 0.4

Y

ITK

D13720

IL2-inducible T-cell kinase

T-cell proliferation & differentiation

2.4 ± 0.4

Y

LCK

M36881

Lymphocyte-specific protein tyrosine kinase

Intracellular signaling

3.5 ± 0.7

Y

NFKB1

M58603

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Transcriptional regulator

2.3 ± 0.4

Y

PDE1C

U40371

Calcium/calmodulin-dependant 3', 5'-cyclic nucleotide phosphodiesterase 1C

Signal transduction

17.4 ± 1.9

Y

PKIA

S76965

Protein kinase (cAmp-dependent) inhibitor alpha

Negative regulation of protein kinase A

2.0 ± 0.3

Y

PPM1G

Y13936

Serine/threonine protein phosphatase PP1-gamma 1 catalytic subunit

Negative regulator of cell stress response/cell cycle arrest

3.2 ± 0.5

Y

PTPN11

D13540

Protein tyrosine phosphatase

Intracellular signaling, cell migration

2.4 ± 0.2

Y

RGS3

AF006610

Regulator of G-protein signaling-3

Inhibition of G-protein mediated signal transduction

3.4 ± 0.3

Y

RORC

U16997

RAR-related orphan receptor C

Inhibition of Fas ligand and IL2 expression

3.1 ± 0.3

Y

ROR1

M97675

Receptor tyrosine kinase-like orphan receptor 1

Unknown

4.0 ± 0.4

Y


Complemented 2D6 mutant had similar results to the wild-type bacterium. Y = Yes; N = No

Jha et al. BMC Microbiology 2010 10:100   doi:10.1186/1471-2180-10-100

Open Data