Comparison of lung parenchyma from mice immunized with COMP-hsp65 or naked hsp65. Lung sections of mice immunized with one intranasal dose of COMP-hsp65 (25 μg) were compared with lung sections from mice that received four intramuscular doses of naked DNA (400 μg), BCG or saline. Thirty days after the last dose, mice were challenged intra-tracheally with M. tuberculosis H37RV and 30 days post infection we performed histological analysis of the lung. (A) non-infected; (B) saline; (C) naked hsp65; (D) COMP-hsp65 and (E) BCG groups. Representative sections of HE staining. Magnifications: ×65.
Rosada et al. BMC Immunology 2008 9:38 doi:10.1186/1471-2172-9-38