Table 9

Alleles reclassified as "unassigned".

Allele

Previous assignment

B pocket match

F pocket match

Comments


A*0102

A01

-

A01 full

Single difference with A*0101 (F to S) at position 9 in B pocket is non-conservative.

A*2404

A24

A24 full

-

F pocket key sequence is similar to A02 and B27 (hydrophobic), so A24 is still likely.

A*3401

A03

-

A03 full

N/K in 63/66 are relatively unique, otherwise similar to A03 in the B pocket.

A*4301

A01

-

A01 full

Q to N in 63 is only difference with A*2601, so A01 is still likely.

B*1301

B62

B62 key

-

Unusual F pocket.

B*1302

B62

B62 key

-

Unusual F pocket.

B*1506

B62

-

B07 B27 B44 B62 full

Single conservative change (Y to F) at position 99 of B pocket, comapred to B*1501; B62 still likely.

B*1521

B62

-

B07 B62 full

S to C change in position 67 is the onlyB pocket difference with B*1501, so B62 is still likely.

B*2708

B27

B27 full

-

Position 77 T to N change is only difference with b*2704, so B27 is still likely.

B*3802

B27

B27 full

-

I to T in position 80 of the F pocket is the only difference with B*3801, so B27 is still likely.

B*4701

B44

-

B27 key

Y to F at position 99 is the only difference with B*4402-3 in the B pocket, so B44 is still likely.

B*4901

B44

B44 full

-

F full pocket is similar to B*3801 (hydrophobic), so B44 is still likely.


Sidney et al. BMC Immunology 2008 9:1   doi:10.1186/1471-2172-9-1

Open Data