Table 1 |
||||
|
Phenotype and function of primary and secondary FDC-like cells as compared with macrophages generated in vitro and with freshly prepared monocytes |
||||
|
Monocytes [day 0] |
Macrophages [day 15] |
Primary FDC-like cells [day 15] |
Secondary FDC-like cells [day 18] |
|
|
|
||||
|
HLA-DR |
+ |
++ |
+ |
++ |
|
CD22 |
- |
- |
± |
± |
|
CD35 (CR1) |
+ |
+ |
+++ |
+++ |
|
CD45 |
+++ |
+++ |
± |
N.D. |
|
CD54 (ICAM-1) |
+ |
- |
- |
++ |
|
CD68 |
++ |
+++ |
+± |
+± |
|
CD106 (VCAM-1) |
- |
- |
- |
+ |
|
AP |
- |
- |
+++ |
+++ |
|
Clustering. |
- |
- |
++ |
+++ |
|
B cell Rosetting |
- |
- |
+++ |
+++ |
|
Emperipolesis |
- |
- |
++ |
++ |
|
Antigen Retention |
- |
- |
+++ |
+++ |
|
|
||||
|
Markers and functions are expressed as absent (-), faintly or few positive cells (+), positive with different intensities (+, ++, +++), variable with respect to donor variations (±). The term, clustering, refers to the ability to establish homotypic and heterotypic aggregates. N.D. not determined. |
||||
|
Heinemann and Peters BMC Immunology 2005 6:23 doi:10.1186/1471-2172-6-23 |
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