Table 5

Immunological markers association with CVID complications
Unit Odds ratio 95% confidence interval p-value
B cells
CD19+ cells/mm3 0.65 [0.36; 1.15] 0.1373
CD27-IgD+ % CD19+ 1.49 [0.89; 2.48] 0.1310
CD27-IgD- % CD19+ 0.54 [0.24; 1.23] 0.1401
CD27 + IgD+ % CD19+ 0.62 [0.34; 1.12] 0.1124
CD27 + IgD- % CD19+ 0.93 [0.29; 0.86] 0.0119
T cells
CD3+ cells/mm3 0.68 [0.40; 1.17] 0,1646
CD4+ cells/mm3 0.45 [0.26; 0.78 ] 0,0046
CD8+ cells/mm3 1.04 [0.66; 1.62 ] 0.8818
CD4+/CD8+ ratio 0.99 [0.63; 1.56 ] 0.9649
CD8+ T cells
CD45RA + CCR7+ % CD8+ 0.69 [0.43; 1.13] 0.1385
CD45RA-CCR7+ % CD8+ 0.75 [0.46; 1.25] 0.2710
CD45RA-CCR7- % CD8+ 1.38 [0.86; 2.20] 0.1800
CD45RA + CCR7- % CD8+ 0.77 [0.48; 1.23] 0.2666
CD8 + CD57+ % CD8+ 1.30 [0.83; 2.06] 0.2567
Activated T cells
CD3 + HLA-DR+ % CD3+ 2.99 [1.56; 5.73] 0.0010
CD4 + HLA-DR+ % CD4+ 2.70 [1.40; 5.23] 0.0032
CD8 + HLA-DR+ % CD8+ 2.75 [1.54; 4.90] 0.0006
Regulatory T cells cells/mm3 0.41 [0.22; 0.78] 0.0065
Natural Killer cells cells/mm3 0.75 [0.46; 1.21] 0.2369
Dendritic cells
Myeloid /ml 0.65 [0.36; 1.17] 0.1532
Plasmacytoid /ml 0.37 [0.18; 0.73] 0.0046
Gammadelta cells cells/mm3 1.30 [0.79; 2.13] 0.3028
Gammadelta 2 cells % GD 0.52 [0.32; 0.85] 0.0087

Univariable logistic regression analysis (Odds ratio per 1 standard deviation).

ALTADIH Cohort, 2007-2010.

Picat et al.

Picat et al. BMC Immunology 2014 15:13   doi:10.1186/1471-2172-15-13

Open Data