Table 1

Summary: comparison of macrophage activation regulatory factors in human pulmonary alveolar proteinosis (PAP) patients and GM-CSF knockout mice
Regulatory factors Associated macrophage phenotype PAP patients GM-CSF knockout mice
GM-CSF M1 Deficient protein, not mRNA [28] Absent [11]
Activin A M1 Deficient [16] Elevated
IL-6 M1 Not done Elevated
CCL5 M1 Not done Elevated
IFNγ M1 mRNA - not elevated (comparable to healthy controls) Elevated [23]
INOS M1 Undetectable in human alveolar macrophages (unpublished observation) Elevated
M-CSF M2 Elevated [30] Elevated [22]
PPARγ M2 Deficient [31] Deficient [31]
CCL2 M2 Elevated [32] Elevated
IL-10 M2 Elevated [29] Elevated
MMP2 M2 Elevated [33] Elevated [33]

Dalrymple et al.

Dalrymple et al. BMC Immunology 2013 14:41   doi:10.1186/1471-2172-14-41

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