Effect of lactobacilli on lung injuries induced by respiratory syncytial virus (RSV) infection. Effect of viable (Lr05) or heat-killed (HkLr05) Lactobacillus rhamnosus CRL1505 (A) and viable (Lr06) or heat-killed (HkLr06) L. rhamnosus CRL1506 (B) nasal administration on lung tissue injuries induced by RSV infection. Lr05, Lr06, HkLr05 or HkLr06 were nasally administered to different groups of mice for 2 consecutive days at a dose of 108 cells/mouse/day. After lactobacilli treatment, mice were nasally challenged with RSV and wet:dry weight ratio, lactate dehydrogenase (LDH) activity and, albumin and protein concentrations in broncho-alveolar lavages (BAL) were studied in different time points after the challenge. The results represent data from three independent experiments. Different letters indicate significant differences (P < 0.05).
Tomosada et al. BMC Immunology 2013 14:40 doi:10.1186/1471-2172-14-40