Effect of lactobacilli on the resistance against respiratory syncytial virus (RSV) infection. Effect of viable (Lr05) or heat-killed (HkLr05) Lactobacillus rhamnosus CRL1505 (A) and viable (Lr06) or heat-killed (HkLr06) L. rhamnosus CRL1506 (B) nasal administration on the resistance against RSV infection. Lr05, Lr06, HkLr05 or HkLr06 were nasally administered to different groups of mice for 2 consecutive days at a dose of 108 cells/mouse/day. After lactobacilli treatment, mice were nasally challenged with RSV and lung virus titers and changes in body weight were studied on different time points after the challenge. The results represent data from three independent experiments. Different letters indicate significant differences (P < 0.05).
Tomosada et al. BMC Immunology 2013 14:40 doi:10.1186/1471-2172-14-40