Effect of lactobacilli on lung injuries induced by the nasal administration of the viral pathogen-associated molecular pattern poly(I:C). Effect of viable (Lr05) or heat-killed (HkLr05) Lactobacillus rhamnosus CRL1505 and viable (Lr06) or heat-killed (HkLr06) L. rhamnosus CRL1506 nasal administration on lung wet:dry weight ratio, lactate dehydrogenase (LDH) activity and, albumin and protein concentrations in broncho-alveolar lavages (BAL) after the challenge with poly(I:C). Lr05, Lr06, HkLr05 or HkLr06 were nasally administered to different groups of mice for 2 consecutive days at a dose of 108 cells/mouse/day. After lactobacilli treatment, mice received three doses of poly(I:C) with 24 hours rest period between each administration. Lung tissue injury markers were studied 24 hours after the third challenge with poly(I:C). The results represent data from three independent experiments. Different letters indicate significant differences (P < 0.05).
Tomosada et al. BMC Immunology 2013 14:40 doi:10.1186/1471-2172-14-40