Open Access Highly Accessed Research article

CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients

Jennifer Pieper1, Jessica Herrath1, Sukanya Raghavan1, Khalid Muhammad1, Ronald van Vollenhoven2 and Vivianne Malmström1*

Author Affiliations

1 Rheumatology Unit, Department of Medicine at Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden

2 Unit for Clinical Therapy Research, Inflammatory Diseases, Karolinska Institute, Solna, Stockholm, Sweden

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BMC Immunology 2013, 14:34  doi:10.1186/1471-2172-14-34

Published: 5 August 2013

Additional files

Additional file 1: Figure S1:

Treg frequency is diminished. PBMCs from baseline, 3 months and 6 months following treatment (n=4) were obtained and multicolor flow cytometry was performed. A general reduction in frequency of several Treg associated markers could be seen (A-F). (A) The graph displays CD4+FOXP3+ Treg, (B) Helios+ T cells, (C) CD4+CD39+ T cells, (D) CD45RA+FOXP3+ Treg, (E) CTLA4+ FOXP3+Treg, and (F) CD39+FOXP3+ Treg.

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