Table 2

Impact of differentially expressed microRNA on gene expression in T-cells between MS patients and controls
microRNA microRNA microarray Impact of microRNA on its targets (mRNA microarray)
Fold change MS/Control P-value TargetScan Miranda
hsa-miR-494 0.14 3.1 × 10-05 1.2 × 10-24 6.0 × 10-81
hsa-miR-15b 0.14 2.5 × 10-03 4.1 × 10-34 5.5 × 10-15
hsa-miR-30c 0.15 7.7 × 10-04 2.8 × 10-13 5.0 × 10-58
hsa-miR-23a 0.16 7.8 × 10-03 2.2 × 10-23 9.8 × 10-63
hsa-miR-197 0.19 5.2 × 10-06 1.6 × 10-12 1.2 × 10-06
hsa-miR-1260b 0.21 9.4 × 10-07 NA 2.3 × 10-16
hsa-miR-125a-5p 0.22 8.2 × 10-03 1.2 × 10-43 5.3 × 10-13
hsa-miR-361-5p 0.24 1.4 × 10-02 1.8 × 10-15 3.9 × 10-32
hsa-miR-320d 0.26 2.8 × 10-03 2.0 × 10-09 7.4 × 10-36
hsa-miR-423-3p 0.26 1.6 × 10-02 5.0 × 10-13 1.8 × 10-03
hsa-miR-1280 0.29 4.7 × 10-03 8.2 × 10-56 8.6 × 10-04
hsa-miR-663 0.32 3.5 × 10-03 5.9 × 10-70 1.8 × 10-28
hsa-miR-423-5p 0.33 2.6 × 10-02 6.1 × 10-96 5.7 × 10-36
hsa-miR-99b 0.36 2.4 × 10-02 3.4 × 10-04 7.6 × 10-03
hsa-miR-339-5p 0.37 4.9 × 10-02 1.5 × 10-35 2.5 × 10-07
hsa-let-7a 0.37 2.9 × 10-02 1.9 × 10-04 3.2 × 10-09
hsa-miR-1979 0.38 1.2 × 10-02 NA 8.1 × 10-09
hsa-miR-3178 0.39 1.0 × 10-02 NA NS
hsa-miR-625 0.41 3.2 × 10-02 3.6 × 10-62 2.3 × 10-09
hsa-miR-150 0.65 3.7 × 10-02 2.1 × 10-68 2.1 × 10-11
hsa-miR-3153 1.14 4.5 × 10-02 NA 2.4 × 10-09

To investigate the impact of the significantly changed microRNAs on gene expression in T-cells we performed Kolmogorov-Smirnov test using the target genes identified in TargetScan and Miranda. NS: not significant, NA: not available in the database. Displayed is the fold change in expression between MS patients and controls.

Jernås et al.

Jernås et al. BMC Immunology 2013 14:32   doi:10.1186/1471-2172-14-32

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