Open Access Highly Accessed Research article

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome

Anne Liese Smylie1, Gordon Broderick14*, Henrique Fernandes1, Shirin Razdan2, Zachary Barnes2, Fanny Collado3, Connie Sol34, Mary Ann Fletcher2 and Nancy Klimas34

Author Affiliations

1 Department of Medicine, University of Alberta, Edmonton, AB, Canada

2 Department of Medicine, University of Miami, Miami, FL, USA

3 Department of Clinical Immunology, Miami Veterans Affairs Medical Center, Miami, FL, USA

4 Institute for Neuro-immune Medicine, Nova South eastern University, Suite 3440 University Park Plaza, 3424 South University Drive, Fort Lauderdale, 33328, FL, USA

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BMC Immunology 2013, 14:29  doi:10.1186/1471-2172-14-29

Published: 25 June 2013

Additional files

Additional file 1: Table S1:

Cohort description of mean values (std. error) with the ANOVA null probability for significance of the group effect. Table S2. Cytokine expression values, mean (std. error) at rest (T0), peak effort (T1) and post-exercise (T2) in healthy male and female subjects. Null probability values are based on a two-tailed t test performed on Log2 transformed data, and Wilcoxon ranksum on untranformed data. Table S3. Cytokine expression values, mean (std. error) at rest (T0), peak effort (T1) and post-exercise (T2) in healthy male subjects, GWI and CFS. Null probability values are based on a two-tailed t test performed on Log2 transformed data, and Wilcoxon ranksum on untranformed data. Table S4. Cytokine expression values, mean (std. error) at rest (T0), peak effort (T1) and post-exercise (T2) in healthy female subjects, GWI and CFS. Null probability values are based on a two-tailed t test performed on Log2 transformed data, and Wilcoxon ranksum on untransformed data.

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Additional file 2: Table S5:

Linear classification models separating female GWI and CFS subjects as well as male GWI and CFS subjects respectively. Performance values correspond to leave-one-out cross validation results.

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Additional file 3: Figure S1:

Age dependent expression of IL-4 in healthy control subjects. In two cohorts separated by age (43 vs. 53 years), healthy control groups show significant differences in IL-4 expression while levels in CFS subjects are comparable across studies [16].

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