Email updates

Keep up to date with the latest news and content from BMC Immunology and BioMed Central.

Open Access Research article

The impact of polymorphisms in STAT6 on treatment outcome in HCV infected Taiwanese Chinese

Yun-Ping Lim12, Yu-An Hsu3, Kun-Hsi Tsai4, Fuu-Jen Tsai5*, Cheng-Yuan Peng67, Wen-Ling Liao8, Dong-Zong Hung12, Ni Tien109, Chien-Yih Lin11* and Lei Wan115*

Author Affiliations

1 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

2 Department of Emergency, Toxicology Center, China Medical University Hospital, Taichung 40447, Taiwan

3 Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan

4 Department of Emergency Medicine, Chi Mei Hospital, Liouying, Tainan, Taiwan

5 School of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan

6 Department of Internal Medicine, China Medical University, Taichung 40402, Taiwan

7 Division of Digestive System and Gastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan

8 Center for Personalized Medicine, China Medical University Hospital, Taichung 40447, Taiwan

9 Department of Laboratory Medicine, China Medical University Hospital, Taichung 40447, Taiwan

10 Department of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan

11 Department of Biotechnology, Asia University, Taichung 41354, Taiwan

For all author emails, please log on.

BMC Immunology 2013, 14:21  doi:10.1186/1471-2172-14-21

Published: 8 May 2013

Abstract

Genetic polymorphisms observed in various disease states associated with sensitivity or resistance to specific treatments have been a robust area of investigation for decades, with the potential to allow clinicians to make evidence-based decisions on the appropriate course of treatment. This study aimed to evaluate whether genetic polymorphisms of the signal transducer and activator of transcription 6 gene (STAT6) could be associated with a sustained virological response (SVR) among patients infected with hepatitis C virus genotypes 1 and 2 (HCV-1 and HCV-2) who were treated with peginterferon plus ribavirin (PEG-IFNα-RBV). We analyzed the associations between SVR to PEG-IFNα-RBV therapy and 4 single nucleotide polymorphisms (SNPs) in STAT6. This study included Taiwanese Chinese patients infected with either HCV-1 (n = 265) or HCV-2 (n = 195) in the presence or absence of an SVR. Among the STAT6 SNPs examined, the dosage effect of the A allele and allele frequency in rs1059513 were inversely correlated with SVR in patients infected with HCV-1 (P = 0.0179 and P = 0.0235, respectively). This effect was not observed in patients infected with HCV-2. The GG, GGG, and GGGC STAT6 haplotypes comprising 2, 3, and 4 SNPs (rs1059513, rs703817, rs324015, and rs3024974) were found to be associated with SVR, and their presence may increase the probability of a successful treatment outcome in patients infected with HCV-1 (P = 0.0273, 0.0352, and 0.0368, respectively). Moreover, a multivariate logistic regression model for predicting an SVR revealed that the presence of the GGGC haplotype carriers mutually affected the outcome of PEG-IFNα-RBV treatment. The presence of STAT6 SNPs and the association with SVR demonstrated that STAT6 polymorphisms might influence the therapeutic outcomes of patients infected with HCV-1 under standard-of-care (SOC) treatment.

Keywords:
Hepatitis C virus; Standard of care treatment; Sustained virological response; Signal transducer and activator of transcription 6