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Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice

Chang-Qing Xia12*, Anna V Chernatynskaya2, Clive H Wasserfall2, Suigui Wan1, Benjamin M Looney2, Scott Eisenbeis3, John Williams3, Michael J Clare-Salzler2 and Mark A Atkinson2

Author Affiliations

1 Department of Hematology, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Xicheng District, Beijing, P.R. China

2 Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA

3 Genzyme Corporation, Framingham, MA, 02142, USA

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BMC Immunology 2012, 13:70  doi:10.1186/1471-2172-13-70

Published: 14 December 2012

Additional files

Additional file 1:

Figure S1. The effect of ATG therapy on absolute numbers of CD4+ and CD8+ T cells. Figure S2. The effect of ATG therapy on depleting spleen cells at day 3 after ATG injection. Figure S3. The proportions of naive and memory CD4+ T cells after CD4+ T cell number recovered from ATG therapy.

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