Table 2

Effect of LPS + PHA stimulation on the release of cytokines (Release of IL-1β, TNF-α, IL-6, IL-10 and IFN-γ in whole blood from wild type subjects (P2X7WT) and subjects homozygous for the Glu496Ala polymorphism (P2X7MUT)a))
Unstimulated p-value Stimulated p-value
P2X7WT P2X7MUT P2X7WT P2X7MUT
IL-1β 2.2 ± 0.16 2.6 ± 0.35 0.381 5,644 ± 3,261 3,440 ± 1,647 0.529
TNF-α 6.6 ± 1.04 7.1 ± 0.33 0.694 7,784 ± 3,470 5,173 ± 1,380 0.504
IL-6 2.5 ± 0.21 2.5 ± 0.35 0.965 13,922 ± 5,790 19,804 ± 8,003 0.064
IL-10 2.4 ± 0.21 2.0 ± 0.10 0.190 291 ± 104 305 ± 167 0.968
IFN-γ 15.4 ± 3.93 13.4 ± 6.38 0.792 701 ± 283 791 ± 144 0.766

a)Data are shown as mean ± SEM.

Wesselius et al.

Wesselius et al. BMC Immunology 2012 13:64   doi:10.1186/1471-2172-13-64

Open Data