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Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

Nils-Holger Zschemisch1*, Silke Glage1, Dirk Wedekind1, Edward J Weinstein2, Xiaoxia Cui2, Martina Dorsch1 and Hans-Jürgen Hedrich1

Author Affiliations

1 Institute of Laboratory Animal Science, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany

2 Sigma Advanced Genetic Engineering Labs, Sigma-Aldrich Corporation, 3050 Spruce Street, St. Louis, Missouri, 63103, USA

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BMC Immunology 2012, 13:60  doi:10.1186/1471-2172-13-60

Published: 8 November 2012

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Additional file 1:

Off-target gene loci:RAG1 ZFN mutagenesis.

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