Effect of plasmid DNA on plasma concentration of NO3-and AVP in LPS-injected rats. Animals were injected with LPS and plasmid DNA at doses of 5, 10 or 20 μg. At 2 (A and C) and 4 (B and D) hours after injection of LPS, blood was collected and the concentration of plasma AVP (A and B) and NO3- (C and D) was determined. Results are expressed as mean ± SD of at least two independent experiments. *, P < 0.05 versus control group injected only with physiologic saline. #, P < 0.05 versus group injected with LPS only.
Malardo et al. BMC Immunology 2012 13:59 doi:10.1186/1471-2172-13-59