Administration of DNA in rats injected with LPS decreases liver expression of IL-6 and TNF-α. Animals were injected with LPS and plasmid DNA at doses of 5 or 10 μg. At 2 (A) or 4 (B) hours after injection of LPS, relative amounts of mRNA for IL-6 (A) and TNF-α (B) from liver were determined. Results are expressed as mean ± SD of at least two independent experiments. *, P < 0.05 versus control group injected with LPS only.
Malardo et al. BMC Immunology 2012 13:59 doi:10.1186/1471-2172-13-59