Figure 3.

Aire^+/+andAire^−/−mTECs show similar DNA methylation profiles. Hierarchical clustering with Euclidean distance of DNA methylation levels estimated by COBRA at 39 mTECany2-T-DMRs and adjacent T-DMRs (upper panel) and 16 previously identified tissue T-DMRs [16,17], which overlap with mTEChyper-T-DMRs (lower panel, Additional file 3: Table S1). DNA methylation levels from 0% to 100% are represented as the continuous gradation from white to black. Each row represents a different gene associated with T-DMRs.