FFO administration regulates the expression of AD-associated cytokines and the Foxp3 transcription factor. Mice with experimental AD were given 100 mg/kg FFO or NFO daily and painted with hydrocort every other day, as described in Figure legend 1. After sacrifice, ear tissues were isolated and used to measure the mRNA expression of inflammatory cytokines including (A) IL-4, (B) IL-13 and INF-γ, and (C) TGF-β and Foxp3 by real-time PCR. Data are representative of 8 mice per group. Values are mean ± S.D (n = 8 mice per group). *P < 0.05; ** P < 0.005; and *** P < 0.001 compared to mice in induction group (A) or NFO-treated group (B and C).
Han et al. BMC Immunology 2012 13:44 doi:10.1186/1471-2172-13-44