The murine GMCSF-PLP TTV induced tolerance and prevented a subsequent episode of EAE. SJL mice were treated with 2 nmoles of GMCSF-PLP (n = 8 each group), 2 nmoles of PLP139-151, or saline on days -21, -14, and -7 before active challenge on day 0 (200 ug of PLP139-151 in CFA). Table 3 and Figure 6 represent the same experiment. Daily clinical scores for mice treated with GMCSF-PLP(139-151) were significantly different from those treated with saline (days 12-15, 18-22, 25-34).
Abbott et al. BMC Immunology 2011 12:72 doi:10.1186/1471-2172-12-72