The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection
1 Laboratory of Infection & Immunology Research, College of Animal Science & Technology, Southwest University, Chongqing, China
2 Parasitology department, College of Animal Science & Technology, Guangxi University, Nanning, China
3 ENVA, UMR BIPAR, Ecopham, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France
BMC Immunology 2011, 12:63 doi:10.1186/1471-2172-12-63
PUBLISHER'S NOTE: The authors would like to retract (see: http://dx.doi.org/10.1186/1471-2172-13-3) the article "The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection" published in BMC Immunology 2011, 12:63. The text and figures in this article have been misappropriated from a different set of experiments using a different parasite, conducted in the laboratory of Prof J Allen and presented in the thesis of K Mylonas. Lead author Dr HongLin Luo accepts full responsibility for this and would like to apologise to colleagues in the lab, the co-authors, Editors and readers. The other authors take no responsibility for the misappropriation.Published: 11 November 2011
Alternatively activated macrophages (AAMϕ) play important roles in allergies and responses to parasitic infections. However, whether signaling through toll-like receptors (TLRs) plays any role in AAMϕ induction when young Fasciola hepatica penetrates the liver capsule and migrates through the liver tissue is still unclear.
The data show that the lack of myeloid differentiation factor 88 (MyD88) has no effect on the AAMϕ derived from the bone marrow (BMMϕ) in vitro and does not impair the mRNA expression of arginase-1, resistin-like molecule (RELMα), and Ym1 in BMMϕs. The Th2 cytokine production bias in splenocytes was not significantly altered in F. hepatica-infected mice in the absence of MyD88 in vitro and in the pleural cavity lavage in vivo. In addition, MyD88-deficiency has no effect on the arginase production of the F. hepatica elicited macrophages (Fe Mϕs), production of RELMα and Ym1 proteins and mRNA expression of Ym1 and RELMα of macrophages in the peritoneal cavity 6 weeks post F. hepatica infection.
The absence of MyD88 has no effect on presence of AAMϕ 6 weeks post F. hepatica infection.