Liver infiltration of CD4+ T cells and CD8+ T cells. CD8 (A: NC, B: CLF, C: ACLF) and CD4 (D: NC, E: CLF, F: ACLF) (×400) showed diffuse non-granular cytoplasmic staining while perforin showed granular cytoplasmic staining. The positive cells mainly infiltrated into the portal areas of the liver. NC, normal control; CLF, HBV-related chronic liver failure; ACLF, HBV-related acute on chronic liver failure.
Niu et al. BMC Immunology 2011 12:47 doi:10.1186/1471-2172-12-47