BMC Immunology

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Open Access Highly Access Research article

The expression of the β-defensins hBD-2 and hBD-3 is differentially regulated by NF-κB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis

Nadine Steubesand1, Karlheinz Kiehne1, Gabriele Brunke1, Rene Pahl1, Karina Reiss3, Karl-Heinz Herzig4, Sabine Schubert5, Stefan Schreiber1,2, Ulrich R Fölsch1, Philip Rosenstiel2 and Alexander Arlt1*

Author Affiliations

1 Department of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

2 Institute of Clinical Molecular Biology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

3 Department of Department of Dermatology and Allergology; University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

4 Institute of Biomedicine, Div of Physiology, and Biocenter of Oulu, University of Oulu, and Department of Internal Medicine, University of Kuopio, Finland

5 Institute for Infection Medicine; University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

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BMC Immunology 2009, 10:36 doi:10.1186/1471-2172-10-36

Published: 12 June 2009

Additional files

Additional file 1:

PMNs induce IL-6 and IL-8 in OE21 cells. Supernatants of OE21 cells kept in culture alone (upper panel) or with with direct contact with 0.5 × 106 PMNs/ml (lower panel) for 24 h were submitted to a peptide arrays detecting a broad panel of chemo- and cytokines.

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