BMC Genomics

official impact factor 4.21

Open Access Highly Access Research article

Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids

Sylvain L'Espérance1,3, Magdalena Bachvarova3, Bernard Tetu2,3, Anne-Marie Mes-Masson4,5 and Dimcho Bachvarov1,3*

Author Affiliations

1 Department of Medicine, Laval University, Québec (Québec), Canada

2 Department of Pathology, Laval University, Québec (Québec), Canada

3 Cancer Research Centre, Hôpital L'Hotel-Dieu de Québec, Centre Hospitalier Universitaire de Québec (CHUQ), Québec (Québec), Canada

4 Department of Medicine, Université de Montréal, Montreal, (Québec) Canada

5 Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CHUM), Institut du cancer de Montréal, Montréal (Québec), Canada

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BMC Genomics 2008, 9:99 doi:10.1186/1471-2164-9-99

Published: 26 February 2008

Additional files

Additional file 1:

Supplemental Table 1. List of common differentially expressed genes (≥1.5-fold) in cisplatin-, topotecan- and paclitaxel-treated OC spheroids

Format: XLS Size: 152KB Download file

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Additional file 2:

Supplemental Table 2. Networks with significant score, commonly affected following cisplatin, topotecan and paclitaxel treatments in OC spheroids

Format: XLS Size: 27KB Download file

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Additional file 3:

Supplemental Table 3. List of differentially expressed genes (≥1.5-fold) in cisplatin-treated OC spheroids

Format: XLS Size: 95KB Download file

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Additional file 4:

Supplemental Table 4. Networks with significant score, affected by cisplatin treatment in OC spheroids

Format: XLS Size: 22KB Download file

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Additional file 5:

Supplemental Table 5. List of differentially expressed genes (≥1.5-fold) in topotecan-treated OC spheroids

Format: XLS Size: 161KB Download file

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Additional file 6:

Supplemental Table 6. Networks with significant score, affected by topotecan treatment in OC spheroids

Format: XLS Size: 25KB Download file

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Additional file 7:

Supplemental Table 7. List of differentially expressed genes (≥1.5-fold) in paclitaxel-treated OC spheroids

Format: XLS Size: 51KB Download file

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Additional file 8:

Supplemental Table 8. Networks with significant score, affected by paclitaxel treatment in OC spheroids

Format: XLS Size: 17KB Download file

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Additional file 9:

Supplemental Table 9. Genes, identified by clustering (the 85 gene list) that are up- or down-regulated in compact OC spheroids in comparison with OC aggregates (≥2-fold, p = 0.03)

Format: XLS Size: 26KB Download file

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