|
Top 25 most significant p53-miRs that target known cell proliferation genes (n = 712). 22/25 of these have been reported in literature as differentially regulated in various cancerous tissues or cancer cell lines (see last column). The p-values represent the probability of a p53-miR targeting a cell proliferation gene purely by chance. |
|||||
| miRNA |
Total Number of Predicted Targets |
Cell Proliferation Genes (n = 712) |
Genes |
p-value |
Cancer miRNA |
|
|
|||||
| hsa-miR-23a |
656 |
44 |
ALDH1A2, BCL11B, CBFA2T2, CBFA2T3, CDC6, CDK5R1, CFDP1, CSE1L, CTNNBIP1, CUL3, CXCL5, ELF4, ELF5, EPS15, GPC4, HDGFRP3, HOXA3, IHH, IL11, IL6R, IRF2, KITLG, LRP5, MAPRE1, MDK, MET, MLLT7, NAP1L1, NOTCH2, NPM1, NR6A1, ODZ1, OPRM1, PRKRIR, PTK2B, RAP1B, SMAD3, SPOCK1, STAT5B, TGFA, TOB2, TRIB1, TUSC2, ZAK |
8.42E-10 |
Yes |
| hsa-miR-92 |
614 |
41 |
ADM, AGGF1, APRIN, BMPR2, BRCA1, BTG2, CBFA2T3, CDC27, CDK6, CDKN1C, CTNNBIP1, CUL3, CXCL5, DERL2, DLG5, EDG1, EPS8, GDF11, HHIP, IGF1R, INSIG1, IRS2, KLF4, LBX1, MITF, NCK2, NF1, NOTCH1, NOX4, PAFAH1B1, PAX3, PCAF, RAP1B, RBM9, SPHK2, TBX3, TCFL5, TOB1, TOB2, UTP20, ZAK |
3.64E-09 |
Yes |
| hsa-miR-32 |
630 |
39 |
ADM, AGGF1, APRIN, BMPR2, BTG2, BTLA, CBFA2T3, CDK6, CDKN1C, CHRM5, CTNNBIP1, CUL3, CXCL5, EDD1, EDG1, EPS8, EVI5, GDF11, HHIP, INSIG1, IRS2, KLF4, LBX1, MITF, NCK2, NOTCH1, NOX4, PAFAH1B1, PAX3, PCAF, RAP1B, RBM9, SPHK2, TBX3, TCFL5, TOB1, TOB2, TTK, ZAK |
6.67E-08 |
Yes |
| hsa-miR-200b |
737 |
42 |
APRIN, BAP1, BCL11B, BHLHB3, CD274, CDC25B, CNOT8, CNTFR, CTBP2, EDNRA, EPS8, ETS1, EVI5, GAB1, GLI3, HDAC4, HELLS, HGF, IL1A, KHDRBS1, KLF10, KLF4, LAMC1, LRP1, LRPAP1, MAFG, MAPRE1, MXD4, MYC, NCK2, NDN, NPM1, PCAF, POU3F2, PROK2, PTHLH, RAP1B, SESN1, SHC1, STAT5A, SUZ12, TOB1 |
2.02E-07 |
Yes |
| hsa-miR-200c |
751 |
42 |
APRIN, BAP1, BCL11B, BHLHB3, BIN1, CD274, CNOT8, CNTFR, CTBP2, EDNRA, EPS8, ETS1, EVI5, GAB1, GLI3, GNAT1, HDAC4, HELLS, HGF, KHDRBS1, KLF10, KLF4, LAMC1, LRP1, LRPAP1, MAFG, MAPRE1, MXD4, MYC, NCK2, NDN, NPM1, PCAF, POU3F2, PROK2, PTHLH, RAP1B, SCG2, SESN1, SHC1, STAT5A, TOB1 |
3.33E-07 |
Yes |
| hsa-miR-195 |
766 |
42 |
ALOX12, AXIN2, BAI1, BDNF, BHLHB3, BIN1, BTG2, CBFA2T3, CD164, CD28, CD40, CDC25A, CDC27, CDK5R1, CHEK1, CUL2, DNAJA2, EFNB1, FGF2, FGF7, FOSL1, HDGF, HOXA3, LAMC1, MAPRE1, MNT, MTCP1, NF2, PAFAH1B1, PDAP1, PIM1, POU3F2, PPAP2A, PPM1D, PRDM4, PRKCD, PTHLH, PURB, RAF1, RARRES1, SESN1, SPEG |
5.60E-07 |
Yes |
| hsa-miR-10a |
230 |
20 |
BCAR1, BCL6, BDNF, CDK4, CTNNBIP1, FLT1, HDAC4, HOXA3, ID4, IFNAR2, JARID2, KLF11, KLF4, MAPRE1, PAFAH1B1, PURB, SERTAD1, SHC1, TRAIP, ZMYND11 |
7.09E-07 |
Yes |
| hsa-miR-10b |
237 |
20 |
BCAR1, BCL6, BDNF, CDK4, CNOT8, CTNNBIP1, FLT1, HDAC4, HOXA3, ID4, IFNAR2, JARID2, KLF11, KLF4, MAPRE1, PAFAH1B1, PURB, SHC1, TRAIP, ZMYND11 |
1.14E-06 |
Yes |
| hsa-miR-24 |
445 |
29 |
ADM, CD164, CD28, CDK5, CDKN1B, CDV3, CNTFR, CSF2, CSK, DCTN2, EDG1, FLT1, GPC4, ING5, INSIG1, MAFG, MNT, MXI1, NUDC, PDGFRA, PIM1, PIM2, PURB, RAP1B, SERTAD1, SESN1, SPHK1, TOB2, ZNF259 |
1.16E-06 |
Yes |
| hsa-miR-203 |
505 |
31 |
ALDH1A2, BCL11B, CASP3, CNTFR, DLG5, EDD1, EDN1, EDNRA, FGG, GLI3, HBEGF, ID4, INSIG1, IRS2, KHDRBS1, MAPRE1, NUMBL, PDAP1, PDGFRA, PPM1D, PRKRIR, PURB, RERG, SMAD1, SMAD3, TBX3, TGFB2, TNFRSF8, TUSC2, USP8, ZMYND11 |
1.77E-06 |
Yes |
| hsa-miR-124a |
1333 |
60 |
ANXA7, AR, BCL11B, BCL6, BTG2, CAPN1, CAV1, CD164, CD276, CDK6, CDKN1A, CUL5, DLG5, DLG7, EFNB1, EMP2, EPS8, ERF, ETS1, EVI1, EVI5, FGFR1OP, GAS1, GNAI2, GPC4, HDAC4, IL9R, ING1, JAG1, JAG2, KLF4, LAMC1, MAP3K11, MAPRE1, MDK, MITF, MXD4, NCK2, NRP1, OVOL2, PAFAH1B1, PBEF1, PDZK1, PGF, PIM1, PRKD1, PTHLH, PURB, QSCN6, RAF1, RAP1B, RARRES1, RHOG, SHC1, SOX9, SPHK1, SPOCK1, TAL1, TOB2, UHRF1 |
1.82E-06 |
Yes |
| hsa-miR-106a |
751 |
40 |
BCL11B, BCL6, BHLHB3, BMPR2, BTG1, BTG2, BTG3, CDKN1A, COL4A3, CSF1, DERL2, E2F1, EBI3, EDD1, EDG1, EFNB1, EREG, FLT1, FZD3, GAB1, HDAC4, KLF11, LIF, MAP3K11, MAPRE1, PAFAH1B1, PCAF, PDGFRA, PPARD, PTEN, PTHLH, PURB, RB1, RBBP7, TAL1, TBX3, TGFB1, TOPORS, TSG101, TUSC2, |
2.13E-06 |
Yes |
| hsa-miR-142-3P |
364 |
25 |
BTG4, BUB1B, CDC14A, CDC25C, CRTAM, EDG3, EHF, ERG, FGFR1OP, FNTB, FOXO1A, FRK, GRN, IL6, IL6ST, KHDRBS1, KLF10, MAP3K11, MLLT7, NUMBL, PCAF, PURB, SKP2, TNFRSF13C, UTP20, |
2.50E-06 |
Yes |
| hsa-miR-33 |
312 |
22 |
APRIN, BCL11B, BMPR2, CD40, CDK6, CKS2, DOCK2, FGA, FGFBP1, HIPK2, HOXC10, IRS2, LGI1, LMO1, NPM1, NPY, PDGFRA, PIM1, PURB, RB1, TSG101, UBE2V2, |
6.53E-06 |
No |
| hsa-miR-372 |
378 |
24 |
BCL6, BTG1, CDCA7, CDK2, CXCR4, DERL2, DNAJA2, E2F1, ERBB4, FGF9, FRK, IRF2, MAP3K11, MNT, PCAF, PRDM4, PURB, RBBP7, TAL1, TOB2, TUSC2, UCHL1, ZFP36L2, ZMYND11, |
1.47E-05 |
Yes |
| hsa-miR-101 |
627 |
33 |
BUB1B, CALCRL, CBFA2T2, CD28, CDC14A, CDC27, CDH5, CDK5R1, CDK6, CSRP2, CUL3, DLG5, ELN, EMP1, FGA, FOXO1A, GLI3, GNB1, ING4, PAX3, PBEF1, PPBP, PPP1R8, PURA, PURB, RAP1B, RBBP7, SOX9, STAMBP, TAL1, TCF19, TGFBR1, TRIB1, |
2.09E-05 |
No |
| hsa-miR-19b |
715 |
36 |
ANXA7, BMPR2, CD164, CDC2L5, CHERP, CLK1, CNTFR, CSE1L, CUL5, DLG5, DNAJA2, EDG1, EPS15, ERBB4, EREG, FOSL1, GCG, GRN, HDAC4, HHIP, HPRT1, ID4, IGF1, IMPDH1, KLF10, LIF, PCAF, POU3F2, PTK2B, RAF1, RAP1B, SMARCA2, SPHK2, ST8SIA1, SUZ12, ZMYND11 |
2.29E-05 |
Yes |
| hsa-miR-196a |
243 |
18 |
ACSL6, ANXA1, ATP6AP1, CASP3, CBFA2T3, CCL23, CDKN1B, ELF4, ERG, IGFBP7, ING5, MYC, NFKBIA, PA2G4, PDGFRA, SSR1, UHRF2, ZMYND11 |
2.30E-05 |
Yes |
| hsa-miR-26b |
633 |
33 |
ADM, BCL6, BTG1, CDC27, CDC2L5, CDK6, CKS2, DLG5, DNAJA2, ENPEP, EPS15, ERBB4, HGF, HIPK2, HOXD13, IGF1, IL6, JAG1, KLF10, KLF4, LIF, MITF, MXI1, PAWR, PBEF1, PDGFRA, PIM1, PRKCD, PRKCQ, PTEN, SMAD1, SMAD4, TOB1, |
2.52E-05 |
Yes |
| hsa-miR-196b |
245 |
18 |
ACSL6, ANXA1, ATP6AP1, CBFA2T3, CCL23, CDKN1B, ELF4, ERG, FOXN1, IGFBP7, ING5, MYC, NF2, NFKBIA, PA2G4, PDGFRA, SSR1, ZMYND11 |
2.57E-05 |
Yes |
| hsa-miR-9 |
737 |
36 |
ARHGEF2, BCL6, BIN1, BTG2, CBFA2T2, CNTFR, COL18A1, CUL4A, CXCR4, EDD1, ERG, ETS1, FGF5, FOXO1A, HDAC4, HES1, ID4, INSIG1, KITLG, LEPRE1, LIFR, NAP1L1, NOTCH2, NOX4, NRP1, ODZ1, PDGFC, PMP22, POU3F2, PPARD, RAP1B, RBM9, SHC1, TBC1D8, TGFBI, UHRF1 |
4.29E-05 |
Yes |
| hsa-miR-29b |
541 |
29 |
BAX, BCL11B, CAV2, CD40, CDC7, CREG1, DUSP22, EPS15, FRAT2, FSCN1, GAB1, HDAC4, INSIG1, JARID2, LAMC1, MAFG, NASP, PDGFB, PDGFC, PINX1, PMP22, PPM1D, PRKRA, PTEN, SETDB1, SMARCA2, SPEG, TNFRSF9, UHRF2 |
4.71E-05 |
Yes |
| hsa-miR-200a |
634 |
32 |
APRIN, ATP8A2, BAP1, BIN1, CD274, CDC14A, CDC25A, CDC25B, CDC2L5, CDK6, CSF3, CTBP2, CTNNB1, CUL3, FLT1, GAB1, HDAC4, HGF, IL1A, IRS2, JAG1, NME1, NRP1, PAX3, PBEF1, POU3F2, PRKD1, SCG2, STAT4, STAT5A, STAT5B, TGFB2 |
6.15E-05 |
Yes |
| hsa-miR-34a |
666 |
33 |
AREG, ARX, BCL11B, BCL6, CBFA2T3, CD28, CD3E, CDC25A, CSF1R, EFNB1, ENPP7, FOSL1, GFER, GNAI2, IL6R, JAG1, KITLG, KLF4, LGI1, MET, MOV10L1, NOTCH1, NOTCH2, NUMBL, PDGFRA, PGF, PRKD1, PURB, SPEG, TGFBI, TOB2, TOPORS, UHRF2 |
6.76E-05 |
Yes |
| hsa-miR-181c |
824 |
38 |
ABI1, ADAMTS1, ADM, ARHGEF2, BCL6, BMPR2, CALCRL, CBFA2T2, CBFA2T3, CKS1B, CUL3, EDG1, EPS15, ERF, ERG, ETS1, FLT1, IL1A, IRS2, LIF, LMO1, NOTCH2, NR6A1, PAFAH1B1, PAWR, PCAF, PDAP1, PDGFRA, PRDM4, PRKCD, PURB, RAP1B, RBBP7, TGFBI, TGFBR1, TGFBR2, USP8, VIP |
8.89E-05 |
Yes |
Sinha et al. BMC Genomics 2008 9:88 doi:10.1186/1471-2164-9-88 |
|||||