An example of spline line curve fitting. In the plot, the replicated measurements (circles) of the time-course were simulated from a step-wise spline function with added independent normal errors. The solid line shows the fits to the data with knots xq at the time points t3 and t6.
Zhang et al. BMC Genomics 2008 9:87 doi:10.1186/1471-2164-9-87