Established neuron-expressed transcripts are highly represented in WT-Pico and IVT-amplified pan-neural samples. A. Histrogram showing percent annotated genes in microarray data sets with known in vivo expression in neurons. All genes with known cellular expression patterns listed in WormBase were used for this comparison. Note significant enrichment for neuronal genes in both the WT-Pico and IVT-amplified pan-neural samples (85–90%) relative to the fraction of annotated genes in WormBase (55%) that show some expression in the C. elegans nervous system. B. Summary of expression data from transcripts enriched in WT-Pico and IVT-amplified pan-neural samples. (FDR = False Discovery Rate, see Methods).
Watson et al. BMC Genomics 2008 9:84 doi:10.1186/1471-2164-9-84