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Differentially expressed genes in the mouse liver after TNF-α treatment and fasting (Sterolgene v0 microarray). Differentially expressed genes in the mouse liver after TNF-α treatment/fasting as detected by the Sterolgene array (α = 0.05). Genes in bold – RT-PCR analysis is consistent with microarray data. |
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| Gene name and function |
Gene symbol |
Log2 ratio |
GeneBank Acc. No. |
|
|
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| Cholesterol biosynthesis |
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| Lanosterol 14α-demethylase |
Cyp51a1 |
1.35 |
BC031813 |
| Sterol-C4-methyl oxidase-like |
Sc4mol |
1.63 |
NM_025436 |
| Bile acid biosynthesis |
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| Sterol 12α-hydroxylase |
Cyp8b1 |
-1.82 |
NM_010012 |
| Cytochrome P450 superfamily |
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| Cytochrome P450, 2f2 |
Cyp2f2 |
-1.72 |
NM_007817 |
| Cytochrome P450, 2j5 |
Cyp2j5 |
-0.68 |
NM_010007 |
| Cytochrome P450, 3a25 |
Cyp3a25 |
-1.56 |
BC028855 |
| Cholesterol side chain cleavage enzyme |
Cyp11a1 |
-0.30 |
NM_019779 |
| Nuclear receptor superfamily |
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| Testis receptor |
Nr2c1 |
-1.31 |
NM_011629 |
| Glucocorticoid receptor |
Nr3c1 |
-0.97 |
NM_008173 |
| Androgen receptor |
Nr3c4 |
-0.71 |
M37890 |
| Other |
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| Glyceraldehyde-3-phosphate dehydrogenase |
Gapd |
0.53 |
NM_008084 |
|
Note. Three mice were used in this experiment. | |||
Režen et al. BMC Genomics 2008 9:76 doi:10.1186/1471-2164-9-76 |
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