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Differentially expressed genes in the mouse liver after fasting (Sterolgene v0 microarray). Differentially expressed genes in the mouse liver after fasting as detected by the Sterolgene array (α = 0.05). |
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| Gene name and function |
Gene symbol |
Log2 ratio |
GeneBank Acc. No. |
|
|
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| Cholesterol biosynthesis |
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| Acetyl-CoA acetyltransferase 2 |
Acat2 |
-1.13 |
NM_009338 |
| Mevalonate kinase |
Mvk |
-0.56 |
NM_023556 |
| Lanosterol 14α-demethylase |
Cyp51a1 |
-1.32 |
BC031813 |
| Sterol-C4-methyl oxidase-like |
Sc4mol |
-2.05 |
NM_025436 |
| NAD(P) dependent steroid |
Nsdhl |
-1.47 |
BC019945 |
| dehydrogenase-like |
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| Sterol C5 desaturase |
Sc5d |
-1.75 |
BC024132 |
| Bile acid biosynthesis |
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| Sterol 12α-hydroxylase |
Cyp8b1 |
0.49 |
NM_010012 |
| Cytochrome P450 superfamily |
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| Cytochrome P450, 1a2 |
Cyp1a2 |
-1.35 |
NM_009993 |
| Cytochrome P450, 3a25 |
Cyp3a25 |
-0.78 |
BC028855 |
| Cytochrome P450, 3a41 |
Cyp3a41 |
-1.91 |
NM_017396 |
| Cholesterol side chain cleavage enzyme |
Cyp11a1 |
0.41 |
NM_019779 |
| Retionic acid hydrolase |
Cyp26a1 |
-0.83 |
NM_007811 |
| Nuclear receptor superfamily |
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| Peroxisome proliferator-activated |
Nr1c1 |
-1.03 |
NM_011144 |
| receptor alpha |
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| Retinoic acid-related orphan |
Nr1f3 |
-0.60 |
NM_011281 |
| receptor gamma |
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| Retinoic acid-related orphan |
Nr1f1 |
-0.54 |
NM_013646 |
| receptor alpha |
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| Liver X receptor beta |
Nr1h2 |
-0.46 |
NM_009473 |
| Constitutive androstane receptor |
Nr1i3 |
0.22 |
NM_009803 |
| Transcription factors |
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| Sterol regulatory element binding transcription factor 2 |
Srebp2 |
-0.60 |
NM_033218 |
| CCAAT/enhancer binding protein alpha |
Cebpa |
-0.38 |
BC028890 |
| Transcription factor 1 |
Tcf1 |
0.17 |
NM_009327 |
| Other |
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| Peptidylprolyl isomerase A |
Ppia |
-0.65 |
NM_008907 |
| Organic anion transporter 1 |
Slco1a1 |
-0.55 |
AY195868 |
| Delta-aminolevulinate synthase 1 |
Alas1 |
0.98 |
NM_020559 |
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Genes in bold – RT-PCR analysis is consistent with microarray data. Cyp3a41 probe cross-hybridizes with Cyp3a11. Note. Three mice were used in this experiment. | |||
Režen et al. BMC Genomics 2008 9:76 doi:10.1186/1471-2164-9-76 |
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