Table 2

Potentially functionally significant amino acid variants

Gene

Amino Acid

MM

MS

HS

RN

GG

BT

CF

XT

MD

TR

SIFT


Slc26a3

His38Asn

His

Asn

His

His

His

His

His

His

His

His

0.13


Dus4L

Cys104Tyr

Cys

Tyr

Cys

Cys

Asn

Cys

Cys

Ser

Cys

Ala

0.18


Cog5

Ser769Ala

Ser

Ala

Ser

Ser

Ser

Ser

Ser

NH

Ser

Ser

0.09


1110049B09Rik

Pro691Ala

Pro

Pro/Ala

Pro

Lys

Pro

Pro

Pro

Pro

Pro

NH

0.11


F730043M19Rik

Asn133Ile

Asn

Ile/Asn

NH

NH

NH

NH

NH

NH

NH

NH

0.00


4930504H06Rik

Met64Val

Met

Val

Met

Met

NH

Met

Met

NH

Met

Phe

0.13


Ahr

Leu348Phe

Leu

Phe

Leu

Leu

Leu

Leu

Leu

Leu

Leu

Leu

0.01


Ser790Gly

Ser

Gly

Asn

Ser

Asp

Asn

Asn

Asn

His

NH

0.15


Ankmy2

Ile369Thr

Ile

Thr

Ile

Thr

Leu

Leu

Leu

Glu

Leu

NH

0.03


Sostdc1

Cys15Ser

Cys

Ser

Cys

Cys

Cys

Cys

Cys

Cys

Cys

Cys

0.00


Ifrd1

Leu449Phe

Leu

Phe

Phe

NH

Phe

Phe

Phe

Leu

Phe

Phe

0.00


EG629820

Gly47Ser

Ser

Ser/Gly

NH

NH

NH

NH

NH

NH

NH

NH

0.00


Gly70Ser

Gly

Ser/Gly

NH

NH

NH

NH

NH

NH

NH

NH

0.00


Asn72Tyr

Asn

Tyr/Asn

NH

NH

NH

NH

NH

NH

NH

NH

0.00


Zfp277

Val21Phe

Val

Val/Phe

Ser

NH

NH

Asp

Asp

NH

NH

NH

0.08


Gln43His

Gln

Gln/His

Gln

NH

Gln

Gln

Gln

Gln

Gln

Gln

0.15


Immp2L

Ala8Val

Ala

Val

Val

Val

Gly

Val

Val

NH

Gly

Gly

0.15


Lrrn3

Ala69Gln

Ala

Ala/Gln

Ala

Ala

Ala

Ala

Ala

NH

Ala

Leu

0.08


Ala671Val

Ala

Ala/Val

Ala

Ala

Ser

Ala

Thr

NH

Ala

NH

0.15


Stxbp6

Ile23Val

Ile

Val

Val

Val

Val

NH

Val

Val

Val

Val

0.12


Bold indicates significant SIFT scores. No known homology (NH), Mus musculus (MM), Mus spretus (MS), Homo sapiens (HS), Rattus norvegicus (RN), Gallus gallus (GG), Bos Taurus (BT), Canis familiaris (CF), Xenopus tropicalis (XP), Monodelphis domestica (MD), and Takifugu rubripes (TR). Sift scores in bold are predicted to be non-tolerated changes.

Mahler et al. BMC Genomics 2008 9:626   doi:10.1186/1471-2164-9-626

Open Data