Open Access Research article

Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

Kimberly L Mahler1, Jessica L Fleming2, Amy M Dworkin3, Nicholas Gladman1, Hee-Yeon Cho2, Jian-Hua Mao4, Allan Balmain4 and Amanda Ewart Toland15*

Author Affiliations

1 Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, OSU Comprehensive Cancer Center, The Ohio State University, OH, USA

2 Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, OH, USA

3 Integrated Biomedical Science Graduate Program, The Ohio State University, OH, USA

4 Cancer Research Institute, University of California, San Francisco, San Francisco, CA, USA

5 Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

For all author emails, please log on.

BMC Genomics 2008, 9:626  doi:10.1186/1471-2164-9-626

Published: 23 December 2008

Additional files

Additional file 1:

Table 1: Genes mapping to Skts5. This table shows a list of all genes mapping to Skts5 including their Ensembl reference number.

Format: XLS Size: 18KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Table 2: All sequence variants identified at Skts5. This table shows all the sequence variants identified in the study, the strain of mouse in which it was found, the amino acid change if applicable, and the rs number if previously entered in dbSNP.

Format: XLS Size: 220KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Table 3: Genes showing strong conservation across species. This table shows a list of amino acid changes that appear to be strongly conserved across species. In red are the amino acids that match M. musculus and in blue are the amino acids that match M. Spretus. The corresponding amino acids in nine species as well as the mouse strains sequenced in the study are shown.

Format: XLS Size: 23KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Table 4: Primers for each exon for sequencing and splice site analysis. This table lists all forward and reverse primers used for sequencing in this study.

Format: XLS Size: 128KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data