Table 3 |
||||
|
Summary of modules from luminal networks |
||||
|
Module |
Constituent hubs |
Function |
Ref. |
Inferred module function |
|
|
||||
|
Luminal ER- |
||||
|
TLR |
CD14 |
Component of LPS receptor |
[38] |
Passive immune |
|
LY96 |
Component of LPS receptor |
[38] |
response |
|
|
TLR4 |
Component of LPS receptor |
[38] |
||
|
KIT/KRT |
CD82 |
Tetraspanin |
[86] |
Kinase signalling |
|
ERBB3 |
ERBB family tyrosine kinase |
[51] |
pathways and |
|
|
GRB7 |
Signalling adaptor protein |
[87] |
cellular structural |
|
|
KIT |
Receptor tyrosine kinase |
[88] |
integrity |
|
|
KRT8 |
Cytoskeletal component |
[89] |
||
|
KRT18 |
Cytoskeletal component |
[89] |
||
|
LYN |
Src family kinase |
[90] |
||
|
MUC1 |
Mucin family cell surface protein |
[91] |
||
|
TEC |
Non-receptor tyrosine kinase |
[92] |
||
|
TNF/FAS |
BCL2 |
Anti-apoptotic protein |
[93] |
Inflammatory |
|
BIK |
Pro-apoptotic protein |
[94] |
response and cell |
|
|
BNIPL |
Putative pro-apoptotic protein |
[95] |
death |
|
|
CCL2 |
Inflammatory chemokine |
[96] |
||
|
CCL5 |
Inflammatory chemokine |
[96] |
||
|
FAS |
Prototype death receptor |
[97] |
||
|
RPS6KA5 |
Serine/threonine kinase; controls transcriptional response to TNF |
[98] |
||
|
TNF |
Pro-inflammatory cytokine |
[97] |
||
|
Luminal ER+ |
||||
|
ESR |
CRELD1 |
Cell adhesion molecule |
[99] |
Multifunctional |
|
ESR1 |
Transcriptional regulator |
[56] |
||
|
GADD45G |
DNA damage response |
[100] |
||
|
GIPC2 |
Mediate cross-talk between cell signalling pathways |
[101] |
||
|
KRT19 |
Cytoskeletal component |
[89] |
||
|
MYCBP |
Interacts with Myc and A-kinase anchoring proteins |
[102] |
||
|
PGR |
Transcriptional regulator |
[39] |
||
|
PTN |
Activation of stromal fibroblasts and stimulation of angiogenesis |
[103] |
||
|
STC2 |
Secreted glycoprotein with possible autocrine or paracrine function |
[104] |
||
|
WFDC2 |
Secreted anti-microbial protein |
[105] |
||
|
ERBB3 |
CD82 |
Tetraspanin |
[86] |
Signal transduction |
|
ERBB3 |
ERBB family tyrosine kinase |
[51] |
||
|
GRB7 |
Signalling adaptor protein |
[87] |
||
|
MLLT4 |
EPHB6 |
Cell-cell interactions/adhesion |
[35] |
Cell adhesion |
|
MLLT4 |
Cell adhesion |
[106] |
||
|
NRXN4 |
Cell-cell interactions/adhesion |
[107] |
||
|
COL8A1 |
COL8A1 |
Extracellular matrix protein |
[108] |
Generation of |
|
EFEMP2 |
Extracellular matrix protein |
[109] |
extracellular matrix |
|
|
KRT |
KRT8 |
Cytoskeletal component |
[89] |
Cellular structural |
|
KRT18 |
Cytoskeletal component |
[89] |
integrity |
|
|
FGG |
FGB |
Extracellular matrix protein |
[110] |
Generation of |
|
FGG |
Extracellular matrix protein |
[110] |
extracellular matrix |
|
|
|
||||
|
Kendrick et al. BMC Genomics 2008 9:591 doi:10.1186/1471-2164-9-591 |
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