Hierarchical clustering of expression patterns of 20 core and rim samples (A). Scatterplot of principal component (PC) 9 against PC10 reveals two clouds representing core (black symbols) and rim samples (white symbols), respectively (B). Proband gene AK098354 shows strong correlation with PC9, containing genes down-regulated in rim population (stationary signature) while cystein rich 61 (Cyr61) exhibits strong correlation with up-regulation pattern of PC10 (migratory signature). GABRIEL was used to detect genes with similar expression patterns to proband genes AK098354 and Cyr61 (C).
Demuth et al. BMC Genomics 2008 9:54 doi:10.1186/1471-2164-9-54