Open Access Highly Accessed Research article

The transcriptomic signature of fasting murine liver

Milka Sokolović12, Aleksandar Sokolović1, Diederik Wehkamp3, Emiel Ver Loren van Themaat3, Dirk R de Waart1, Lisa A Gilhuijs-Pederson3, Yuri Nikolsky4, Antoine HC van Kampen3, Theodorus BM Hakvoort1 and Wouter H Lamers1*

Author Affiliations

1 AMC Liver Center, Academic Medical Center, University of Amsterdam, The Netherlands

2 Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands

3 Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands

4 GeneGo, Inc., St. Joseph, MI, USA

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BMC Genomics 2008, 9:528  doi:10.1186/1471-2164-9-528

Published: 6 November 2008

Additional files

Additional file 1:

Supplementary tables. Supplementary table 1 shows amino-acid concentrations in plasma after 0, 12, 24, 48 and 72 hours of fasting. Supplementary table 2 shows qPCR validation of microarray data. Supplementary table 3 contains gene-specific primer sequences, product lengths and annealing temperatures.

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Additional file 2:

Fold changes in liver response to fasting. The file contains lists of all the genes significantly regulated in the liver (≥ 1.4 fold) per time point of fasting.

Format: XLS Size: 128KB Download file

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Additional file 3:

MetaCore legend. The file contains a legend for the pathways and the network created in MetaCore suite shown in the Figures 7, 8 and 10.

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