Transcriptional regulatory networks of differentially expressed functional gene categories. Candidate transcription factors are shown in rectangular boxes and functional categories of genes are in ovals. The strength of the connections between TFs and functional gene categories are illustrated as arrows of different shade/thickness, corresponding to the number of genes in each functional category that have binding sites for specific TFs (grey, 1(2) genes; thin black, 2(3) – 3(4) genes; heavy black, >3(4) genes, numbers in parentheses refer to cluster 3 only). The shade/thickness of borders on the ovals represents the number of genes in that category relative to the total number of genes in the cluster (thick, >15%; thin, 10–15%; grey, <10%). Open ovals are categories not associated with any significantly enriched transcription factor binding site in that cluster. Cluster 1 was omitted in view of the small number of genes involved.
Juskeviciute et al. BMC Genomics 2008 9:527 doi:10.1186/1471-2164-9-527