Figure 5.

Gene Ontology analysis of up-regulated transcripts in ρ⁰ cells whose variance is strongly influenced by mtDNA status. The directed acyclic graph (DAG) represents the relationships of categories (shown in red) that are enriched for transcripts where mtDNA status accounted for over 50% of the observed variance in gene expression and are more abundant in vitro (i.e. cell culture) and/or in vivo (i.e. xenograft) in A549 ρ⁰ cells relative to parental A549 cells. All 229 probe sets used in this analysis are provided in Additional File 11. The names of genes in terminal categories are provided the blue.