Alignment of the beta-subdomain of Geobacter CheR homologs with E. coli and S. enterica CheR. Based on homology, the Geobacter CheRs were divided into three groups. Two groups (A and B) displayed significant identity with residues important for binding pentapeptide (highlighted in grey) and the third group (C) did not. Gene positioning provides further evidence that the group A and B homologs bind to MCPs containing the C-terminal pentapeptide: these homologs are located in che clusters with pentapeptide-containing MCPs (Figure 1). Group A consists of two CheR homologs that are located near two class-36 H MCPs. The consensus pentapeptide of the MCPs that are cognate to the Group B CheR homologs, EFEKF, is found in class-34 H MCPs.
Tran et al. BMC Genomics 2008 9:471 doi:10.1186/1471-2164-9-471