Table 1

Signal peptide-containing proteins in individual and core secretomes. Only sequences containing 0–2 transmembrane domains (TMDs) as predicted by TMHMM are shown.

Function
CcI3*
ACN*
EAN*
Core secretome
Core Frankia-specific

Cell Wall/Growth
14 (4)
13 (6)
15 (8)
17
6
Hydrolase
10 (9)
17 (9)
21 (6)
12
4
Metabolism
42 (99)
55 (159)
56 (163)
59
7
Regulation
10 (15)
13 (19)
11 (20)
10
2
Solute-binding
18 (1)
28 (8)
62 (12)
14
4
Hypothetical
103 (110)
153 (177)
181 (175)
49
29

Total
197 (238)
279 (378)
346 (384)
161
52

* Numbers outside parentheses are predicted to contain signal peptides by both SignalP methods (NN and HMM); numbers inside parentheses are additional proteins predicted to contain a signal peptide by only one method.

Orthologous proteins present in all strains with a signal peptide predicted in two or three strains

Frankia-specific: when CcI3 sequences from the core secretome list were BLAST searched against four closest actinobacterial relatives, no hits retrieved at an E value cutoff of 10-20

Mastronunzio et al. BMC Genomics 2008 9:47   doi:10.1186/1471-2164-9-47