Table 2 |
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Adrenaline regulated genes of S. Typhimurium |
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A |
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Adrenaline Upregulated genes |
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KEGG annotation |
Product |
Fold change |
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Transport and metabolism |
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STM0192, fhuC |
ATP-binding component of hydroxymate-dependent iron transport |
2.3 |
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STM3159, exbB |
uptake of enterochelin; tonB-dependent uptake of B colicins |
2.2 |
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STM0191, fhuA |
outer membrane protein receptor for ferrichrome |
2.0 |
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STM3158, exbD |
uptake of enterochelin; tonB-dependent uptake of B colicins |
2.0 |
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STM0596,entE |
2,3-dihydroxybenzoate-AMP ligase |
1.8 |
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STM3506, feoB |
ferrous iron transport protein B |
1.8 |
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STM3505,feoA |
ferrous iron transport protein A |
1.8 |
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STM2861, sitA |
fur regulated Salmonella Mn transporter |
1.6 |
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STM2862, sitB |
fur regulated Salmonella Mn transporter |
1.5 |
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Oxidative Stress |
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STM4055, sodA |
superoxide dismutase |
1.9 |
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Function unknown |
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STM1728, yciG |
putative cytoplasmic protein |
1.8 |
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STM2263, yojI |
putative ABC-type multidrug/protein/lipid transport system |
1.7 |
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STM1586 |
putative periplasmic protein, similar to E. coli putative receptor |
1.7 |
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STM1729,yciF |
putative cytoplasmic protein |
1.7 |
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B |
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Adrenaline Downregulated genes |
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KEGG annotation |
Product |
Fold change |
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Transport and metabolism |
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STM2299,yfbG (pmrI) |
transformylase |
0.4 |
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STM1935, ftn |
cytoplasmic ferritin |
0.4 |
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STM2297, yfbE (pmrH) |
4-amino-4-deoxy-L-arabinose LPS-modifying enzyme |
0.5 |
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STM2298, pmrF |
glycosyl transferase |
0.5 |
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Surface structure |
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STM1176, flgD |
flagellar hook capping protein |
0.7 |
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SPI1-5 |
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STM2899, invF |
invasion protein |
0.6 |
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Regulators, Signal Transduction |
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STM2301, pqaB (pmrK) |
polymyxin B resistance |
0.6 |
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STM3216 |
putative methyl-accepting chemotaxis protein II, aspartate sensor receptor |
0.7 |
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Function unknown |
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STM1936, yecH |
putative cytoplasmic protein |
0.5 |
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STM4293, yjdB |
putative integral membrane protein |
0.6 |
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STM2300, pmrJ |
cytoplasmic protein |
0.6 |
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C |
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Microarray Validation |
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Fold change |
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KEGG annotation |
Product |
Microarrays |
qPCR |
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|
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STM0191, fhuA |
outer membrane protein receptor for ferrichrome |
2.03 |
2.46 |
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STM0596, entE |
2,3-dihydroxybenzoate-AMP ligase |
1.80 |
1.29 |
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STM4055, sodA |
superoxide dismutase |
1.90 |
1.18 |
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STM2297, yfbE (pmrH) |
4-amino-4-deoxy-L-arabinose LPS-modifying enzyme |
0.45 |
0.45 |
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STM2899, invF |
invasion protein |
0.64 |
0.57 |
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Karavolos et al. BMC Genomics 2008 9:458 doi:10.1186/1471-2164-9-458 |
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