Table 1

Gene pairs in human genome that share most 5' exons and promoters with little coding similarities

Gene 1
Chr.
Strand
Gene 1 start *
Gene 2
Gene 2 start
Coexpression Correlation Coefficient
P-value (**)
Note

LEPOT
1
+
65658906
LEPR
65658905
-0.15
0.73 (103)


KLHL23
2
+
170259246
PHOSPHO2
170259220
N/A
N/A (0)


NAT6
3
-
50308836
HYAL3
50305265
0.33
0.16 (103)


TMED7
5
-
114977101
TICAM2
114942246
0.56
0.04 (105)


ITGA1
5
+
52119892
PELO
52119530
0.42
0.09 (95)


MUTED
6
-
7959212
TXNDC5
7826748
0.18
0.30 (107)


HIST1H2AD
6
-
26306990
HIST1H3D
26304990
0.77
<0.01 (94)
Little coding similarity

LOC552891
9
+
113433486
DNAJC25
113433483
N/A
N/A (0)
One is a fusion gene of two adjacent genes

TRIM6-TRIM34
11
+
5574461
TRIM6
5573922
N/A
N/A
One is a fusion gene of two adjacent genes

HOXC4
12
+
52696908
HOXC6
52696908
0.54
0.04 (103)
some coding similarity; HOXC5 also shares exon 1 with these two genes

ANG
14
+
20222608
RNASE4
20222211
0.77
<0.01 (104)


SPESP1
15
+
67009918
NOX5
67009917
0.17
0.32 (68)


SULT1A4
16
+
29373901
GIYD2
29373375
N/A
N/A (0)


SULT1A3
16
+
30113243
GIYD1
30112717
N/A
N/A (0)
Duplication of the SULT1A4/GIYD2 pair

TNFSF12-TNFSF13
17
+
7393139
TNFSF12
7393098
N/A
N/A (0)
One is a fusion gene of two adjacent genes; structure conserved in mouse

NME1
17
+
46585918
NME1-NME2
46585918
N/A
N/A (0)
One is a fusion gene of two adjacent genes

NUP62
19
-
55101893
IL4I1
55084722
-0.11
0.68 (106)


PEG3
19
-
62015614
ZIM2
61977731
0.34
0.14 (75)


ADAT3
19
+
1856416
SCAMP4
1856372
N/A
N/A (0)


FASTKD5
20
-
3075164
UBOX5
3036218
-0.05
0.61 (105)
Structure conserved in mouse

RBM12
20
-
33700290
CPNE1
33677379
0.47
0.06 (106)
Structure conserved in mouse

BAGE
21
-
10079666
BAGE4
10042712
N/A
N/A


C22orf29
22
-
18213668
GNB1L
18155937
0.06
0.45 (104)


ZBED1
X
-
2414454
DHRSX
2147546
0.42
0.09 (103)


* chromosomal positions are based on NCBI human genome Build 36.3.

** refers to the number of experiments where both genes in that gene pair appeared together.

Yang et al. BMC Genomics 2008 9:456   doi:10.1186/1471-2164-9-456