Table 1

Highly conserved genes with an E(CG)-bearing promoter.

A – Human genes with E(CG)-bearing promoters across bilaterian orthologs

ABCF1*

ESF1*

NOL11*

RIOK1*

ATHL1

GNL2*

NOL14*

RPL11*

BXDC1*

GRWD1*

NOL5_HUMAN*

RPL8*

BXDC5*

HEATR1*

NOL5A*

RRP12*

BYSL*

HTF9C_HUMAN*

NOL6*

RRP9*

C1orf107*

IMP4*

NOLA1*

RRS1*

C1orf181*

KAD6_HUMAN*

NP_060822.2*

SDAD1*

C6orf66

KIAA0020*

NP_079425.3

SRM*

CCDC86*

KIAA0409*

PAQR3

SURF6*

CEBPZ*

KLHDC4

PFAS

TIMM10

CIRH1A*

LYAR*

PNO1*

TRMT1*

DDX18*

MBIP

POLR1B*

UMPS

DDX51*

MEN1

POLR1E*

UTP20*

DDX52*

MRTO4*

POLRMT

WDR3*

DDX54*

MYBBP1A*

PRMT3

WDR36*

DHX37*

NAT10*

PWP1*

WDR75*

DPH5

NHP2L1*

PWP2*

WDR89

DUS3L*

NLE1*

QTRTD1*

EBAG9

NM_005452*

RBM19*

ELP3

NOL1*

RCL1*

B – Human genes with E(CG)-bearing promoters across holozoan orthologs

ATIC

EBNA1BP2*

MRTO4*

PRMT3*

BMS1L*

ESF1*

NAT10*

PWP1*

BXDC1*

EXOSC1*

NHP2L1*

PWP2*

BXDC5*

FARSLB*

NLE*

SLC25A32

BYSL*

GTPBP9

NOL14*

SRM*

DDX4

KAD6_HUMAN*

NOP5*

TRMT1*

DDX54*

KLF15

PNO1*

VPS29

DHX37*

LYAR*

POLR3K*

DPH5

MCCC2

PRDX4

(A) A list of all human genes with orthologous fly genes containing an E(CG) tightly linked to the core promoter in both orthologs. These genes have an E(CG) ± 600 bp and ± 80 bp from the transcriptional initiation site in the pair of human and fly orthologs, respectively. Genes with asterisks are known to be involved in ribosome biogenesis. See Additional file 1 for a more exhaustive list of genes described in this study. (B) A list of all human genes that have been evolutionarily maintained with E(CG)-bearing promoters across orthologous holozoan loci (humans, flies, cnidarians, and choanoflagellates). These genes have an E(CG) ± 600 bp from the annotated 5'-end in each genome. Missing from this list are genes that may be E(CG)-bearing in a genome but are not yet annotated by full-length transcripts. Genes with asterisks are known to be involved in ribosome biogenesis. See Additional file 1 for a more exhaustive list of genes described in this study.

Brown et al. BMC Genomics 2008 9:442   doi:10.1186/1471-2164-9-442