Table 3 |
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|
Selected UCR Motifs |
|||||||||
|
Proportion of UCRs with Motif |
Median Motifs per UCR |
||||||||
|
Motif |
FET p value |
BH |
Enriched over genome? |
miRNA |
siRNA |
PIWI |
miRNA |
siRNA |
PIWI |
|
|
|||||||||
|
NFkB2 |
not sig.^ |
not sig. |
No |
0.188 |
0.250 |
0.100 |
1.0 |
1.0 |
1.0 |
|
NFkB4 |
not sig. |
not sig. |
No |
0.313 |
0.438 |
0.460 |
1.0 |
1.0 |
1.0 |
|
NFkB7* |
not sig. |
not sig. |
No |
0.188 |
0.375 |
0.280 |
1.0 |
1.0 |
1.0 |
|
BRC_Z1 |
not sig. |
not sig. |
No |
0.813 |
0.313 |
0.540 |
1.0 |
1.0 |
1.0 |
|
BRC_Z2 |
not sig. |
not sig. |
No |
0.563 |
0.688 |
0.620 |
1.0 |
1.0 |
1.0 |
|
Pathway-specific |
miRNA |
siRNA |
PIWI |
||||||
|
M19 (miRNA) |
not sig. |
not sig. |
Yes |
0.188 |
0.100 |
0.033 |
4.5 |
1 |
1 |
|
M21 (miRNA) |
not sig. |
not sig. |
Yes |
0.219 |
0.100 |
0.067 |
2 |
2 |
1 |
|
M24 (siRNA) |
not sig. |
not sig. |
Yes |
0.063 |
0.400 |
0.200 |
1 |
14 |
1 |
|
M26 (siRNA) |
not sig. |
not sig. |
Yes |
0.031 |
0.250 |
0.033 |
2 |
3 |
2 |
|
M30 (PIWI) |
not sig. |
not sig. |
Yes |
0.000 |
0.000 |
0.060 |
NA |
NA |
5 |
|
Species-Specific |
Aae |
Aga |
Cpi |
Aae |
Aga |
Cpi |
|||
|
M1 (Aedes) |
not sig. |
not sig. |
Yes |
0.188 |
0.100 |
0.033 |
1.5 |
1.5 |
1 |
|
M2 (Aedes) |
not sig. |
not sig. |
Yes |
0.219 |
0.100 |
0.067 |
2 |
2 |
1 |
|
M3 (Aedes) |
not sig. |
not sig. |
Yes |
0.094 |
0.000 |
0.033 |
9 |
NA |
1 |
|
M7 (Anopheles)# |
not sig. |
not sig. |
Yes |
0.063 |
0.400 |
0.200 |
10.5 |
1.5 |
1 |
|
M8 (Anopheles) # |
not sig. |
not sig. |
Yes |
0.031 |
0.250 |
0.033 |
10 |
1 |
1 |
|
M9 (Anopheles) |
< 0.001 |
0.002 |
No |
0.000 |
0.400 |
0.300 |
NA |
6 |
1 |
|
M12 (Culex)+ |
not sig. |
not sig. |
Yes |
0.031 |
0.000 |
0.067 |
1 |
NA |
21 |
|
M13 (Culex)+ |
not sig. |
not sig. |
Yes |
0.031 |
0.000 |
0.067 |
1 |
NA |
21 |
|
M17 (Culex) |
< 0.001 |
0.002 |
No |
0.094 |
0.100 |
0.533 |
1 |
1 |
1 |
|
|
|||||||||
|
"^", see Additional File 4 for details. "*", for NFkB7 only, significance scores were based on the presence of 2 or more hits per UCR. "#", enriched in an siRNA pathway specific manner. "+", enriched in an miRNA pathway specific manner. "BH", Benjamini-Hochberg test, cut-off = 0.05. "FET", Fisher's Exact test, cutoff = 0.01. "NA", not applicable. "Aae", Ae. aegypti, "Aga", An. gambiae, "Cpi", Cx. pipiens. |
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|
Campbell et al. BMC Genomics 2008 9:425 doi:10.1186/1471-2164-9-425 |
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