Table 1

List of 138 S. aureus genes that were most strongly affected by OPP and are discussed in this report categorized by their related function. The microarray results are the mean of five replicates of each gene.

20 min

60 min


Affymetrix Probe ID

ORF no.

p-value

Fold change

p-value

Fold change

Description

Gene symbol

Functional class


Group I: Upregulation (20 min) – Upregulation (60 min) 18 genes


sa_c6812s5946_a_at

SA0265

8.55E-06

2.1

8.55E-06

3.1

peptidoglycan hydrolase (surface antigen)

lytM

Cell envelope biogenesis, outer membrane

sa_c7382s10191_a_at

SA0423*

5.16E-07

8.1

5.16E-07

19.4

hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase)

General function prediction only

sa_c7698s6703_a_at

SA0519

0.00293

2.8

0.00293

2.5

Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein

sdrC

Cell envelope biogenesis, outer membrane

sa_c8045s7032_at

SA0620

1.27E-06

7.6

1.27E-06

5.6

hypothetical protein, similar to secretory antigen precursor SsaA

General function prediction only

sa_c592s9345_a_at

SA0905

4.83E-08

5.7

4.83E-08

7.0

N-acetylglucosaminidase (major autolysin)

atl

Cell envelope biogenesis, outer membrane

sa_c1007s793_a_at

SA1003

7.81E-06

3.7

7.81E-06

4.2

fibrinogen-binding protein precursor

hypothetical protein

sa_c4394s3743_a_at

SA1898

7.99E-05

6.1

7.99E-05

5.8

hypothetical protein, simialr to SceD precursor

hypothetical protein

sa_c4612s9984cs_s_at

SA1972

0.00267

2.2

0.00267

2.7

multidrug resistance protein (efflux transporter)

hypothetical protein

sa_c5066s4362_a_at

SA2093*

0.00025

6.8

0.00025

9.0

hypothetical protein, similar to secretory antigen precursor SsaA

ssaA

General function prediction only

sa_c5082s4380_a_at

SA2097*

3.71E-05

6.9

3.71E-05

11.5

hypothetical protein, similar to secretory antigen precursor SsaA

General function prediction only

sa_c342s182_a_at

SA2142

9.36E-07

3.6

9.36E-07

3.6

multidrug resistance protein B (drug efflux transporter)

hypothetical protein

sa_c5274s4572_a_at

SA2143

1.24E-07

3.9

1.24E-07

4.1

multidrug resistance efflux pump

hypothetical protein

sa_c5652s4904_a_at

SA2206

0.00082

2.5

0.00082

2.8

Immunoglobulin G binding protein A precursor

sbi

Cell envelope biogenesis, outer membrane

sa_c6151s5333_a_at

SA2332

0.00019

7.8

0.00019

8.6

hypothetical protein, similar to secretory antigen precursor SsaA

General function prediction only

sa_c6250s5428_a_at

SA2353*

1.91E-05

10.2

1.91E-05

13.8

secretory antigen precursor SsaA homolog

General function prediction only

sa_c9402s8223_a_at

SA2355*

3.23E-06

8.5

3.23E-06

9.4

transcriptional regulator, MARR family

hypothetical protein

sa_c6259s5439_a_at

SA2356

3.43E-06

6.5

3.43E-06

6.9

immunodominant antigen A

isaA

Cell envelope biogenesis, outer membrane

sa_c6506s5675_a_at

SA2423

0.00148

2.9

0.00148

3.5

fibrinogen-binding protein A, clumping factor

clfB

Posttranslational modification, protein turnover, chaperones


Group II: Upregulation (20 min) – No change (60 min) 28 genes


sa_c7511s6531_a_at

SA0459

0.000138

2.3

ribosomal protein L25 (general stress protein Ctc)

rplY

Translation, ribosomal structure and biogenesis

sa_c7621s6634_a_at

SA0497

7.95E-05

2.2

50S ribosomal protein L10; ribosomal protein L10 (BL5)

Translation, ribosomal structure and biogenesis

sa_c7625s6638_at

SA0498

5.07E-05

3.5

50S ribosomal protein L7:L12; ribosomal protein L7:L12

Translation, ribosomal structure and biogenesis

sa_c1147s928_a_at

SA1041

0.00142

2.8

uracil phosphoribosyltransferase; Pyrimidine operon regulatory protein pyrR

Nucleotide transport and metabolism

sa_c1151s932_a_at

SA1042

0.000143

6.7

uracil permease (uracil transporter)

pyrP

Nucleotide transport and metabolism

sa_c9991s8687_a_at

SA1043

7.66E-05

6.5

aspartate carbamoyltransferase catalytic chain (Aspartate transcarbamylase) (ATCase)

pyrB

Nucleotide transport and metabolism

sa_c1155s937_a_at

SA1044

0.000101

6.0

dihydroorotase, dihydroorotase-like

pryC

Nucleotide transport and metabolism

sa_c1159s942_a_at

SA1045

0.000161

5.1

carbamoyl-phosphate synthase, arginine-specific, small chain

pyrAA

Amino acid transport and metabolism, Nucleotide transport and metabolism

sa_c1165s946_a_at

SA1046

0.00018

3.3

carbamoyl-phosphate synthase, arginine-specific, large chain

carB

Amino acid transport and metabolism, Nucleotide transport and metabolism

sa_c1167s950_a_at

SA1047

0.000788

3.3

orotidine 5-phosphate decarboxylase

pyrF

Nucleotide transport and metabolism

sa_c9989s8682_a_at

SA1048

0.00107

3.0

orotate phosphoribosyltransferase

pyrE

Nucleotide transport and metabolism

sa_c1302s1077_a_at

SA1084

0.000221

2.7

50S ribosomal protein L19; ribosomal protein L19

rplS

Translation, ribosomal structure and biogenesis

sa_c4792s4098_at

SA2022

0.000417

2.1

50S ribosomal protein L17; ribosomal protein L17

rplQ

Translation, ribosomal structure and biogenesis

sa_c4824s4130_a_at

SA2029

2.76E-05

2.1

50S ribosomal protein L15; ribosomal protein L15

rplO

Translation, ribosomal structure and biogenesis

sa_c4836s4142_at

SA2032

0.00024

2.1

50S ribosomal protein L18; ribosomal protein L18

rplR

Translation, ribosomal structure and biogenesis

sa_c9951s8647_at

SA2033

0.000342

2.6

50S ribosomal protein L6; ribosomal protein L6 (BL8)

rplF

Translation, ribosomal structure and biogenesis

sa_c4848s4156_at

SA2035

0.0021

2.1

50S ribosomal protein L5; ribosomal protein L5 (BL6)

rpsN

Translation, ribosomal structure and biogenesis

sa_c4852s4158_at

SA2036

0.00267

2.1

50S ribosomal protein L24; ribosomal protein L24 (BL23)

rplX

Translation, ribosomal structure and biogenesis

sa_c10191s8871_a_at

SA2038

0.0026

2.8

30S ribosomal protein S17; ribosomal protein S17 (BS16)

rpsQ

Translation, ribosomal structure and biogenesis

sa_c4860s4166_at

SA2039

0.00204

2.5

50S ribosomal protein L29; ribosomal protein L29

rpmC

Translation, ribosomal structure and biogenesis

sa_c4864s4170_at

SA2040

0.000749

2.7

50S ribosomal protein L16; ribosomal protein L16

rplP

Translation, ribosomal structure and biogenesis

sa_c4868s4175_a_at

SA2041

0.0024

2.8

30S ribosomal protein S3; ribosomal protein S3 (BS3)

rpsC

Translation, ribosomal structure and biogenesis

sa_c4876s4184_at

SA2043

0.00405

2.8

30S ribosomal protein S19; ribosomal protein S19 (BS19)

rpsS

Translation, ribosomal structure and biogenesis

sa_c9959s8654_a_at

SA2044

0.000888

2.5

50S ribosomal protein L2; ribosomal protein L2 (BL2)

rplB

Translation, ribosomal structure and biogenesis

sa_c10192s8875_a_at

SA2045

0.00434

2.7

50S ribosomal protein L23; ribosomal protein L23

rplW

Translation, ribosomal structure and biogenesis

sa_c4880s4187_at

SA2046

0.00283

2.8

50S ribosomal protein L4; ribosomal protein L4

rplD

Translation, ribosomal structure and biogenesis

sa_c4888s4195_a_at

SA2047

0.00069

2.3

50S ribosomal protein L3; ribosomal protein L3 (BL3)

rplC

Translation, ribosomal structure and biogenesis

sa_c9963s8658_a_at

SA2048

0.00245

2.4

30S ribosomal protein S10; ribosomal protein S10 (BS13)

rpsJ

Translation, ribosomal structure and biogenesis


Group III: No change (20 min) – Upregulation (60 min) 8 genes


sa_c10571s9056_a_at

SA0845

0.000581

2.5

putative oligopeptide ABC transporter integral membrane protein (fragment)

oppB

Amino acid transport and metabolism, Inorganic ion transport and metabolism

sa_c324s166_a_at

SA0846

0.00019

2.4

probable peptide ABC transporter permease ABC transporter protein

oppC

Amino acid transport and metabolism, Inorganic ion transport and metabolism

sa_c328s170_a_at

SA0847

0.00293

2.2

probable peptide ABC transporter ATP-binding ABC transporter protein

oppD

Amino acid transport and metabolism, Inorganic ion transport and metabolism

sa_c332s172_a_at

SA0848

9.13E-05

2.2

probable peptide ABC transporter ATP-binding ABC transporter protein

oppF

Amino acid transport and metabolism

sa_c5349s4625_a_at

SA0950

0.0022

2.2

ABC transporter ATP-binding protein – spermidine:putrescine transport

potA

Amino acid transport and metabolism

sa_c795s596_a_at

SA0952

0.00536

2.2

ABC transporter membrane-spanning permease – spermidine:putrescine transport

potC

Amino acid transport and metabolism

sa_c803s604_a_at

SA0953

0.00987

2.2

spermidine:putrescine ABC transporter, spermidine: putrescine-binding periplasmic protein (potD) homolog

potD

Amino acid transport and metabolism

sa_c8848s7783_a_at

SA1601

0.000923

2.3

CRCB, CrcB-like protein

Cell division and chromosome partitioning


Group IV: Downregulation (20 min) – Downregulation (60 min) 27 genes


sa_c5061s4360_a_at

SA0229

4.85E-07

-5.8

4.85E-07

-4.8

dipeptide ABC transporter, periplasmic dipeptide-binding protein (dppA)

Amino acid transport and metabolism

sa_c736s544_a_at

SA0937

0.00365

-2.9

0.00365

-3.5

cytochrome D ubiquinol oxidase subunit I

Energy production and conversion

sa_c740s548_a_at

SA0938

0.00375

-2.9

0.00375

-3.4

cytochrome D ubiquinol oxidase subunit II homolog

Energy production and conversion

sa_c1659s1395_a_at

SA1164*

0.000431

-8.9

0.000431

-3.4

homoserine dehydrogenase (HDH)

dhoM

Amino acid transport and metabolism

sa_c1665s1401_a_at

SA1165

0.00011

-8.3

0.00011

-3.2

threonine synthase (EC 4.2.3.1) homolog thrC

thrC

Amino acid transport and metabolism

sa_c1669s1406_a_at

SA1166

5.06E-05

-11.5

5.06E-05

-3.8

homoserine kinase (thrB)

thrB

Amino acid transport and metabolism

sa_c1872s1598_a_at

SA1213

0.00127

-2.8

0.00127

-2.4

probable peptide ABC transporter permease ABC transporter protein

opp-2C

Amino acid transport and metabolism, Inorganic ion transport and metabolism

sa_c1876s1602_a_at

SA1214

8.58E-06

-3.7

8.58E-06

-3.0

putative oligopeptide ABC transporter integral membrane protein (fragment)

opp-2B

Amino acid transport and metabolism, Inorganic ion transport and metabolism

sa_c1912s1635_a_at

SA1225*

8.90E-06

-54.6

8.90E-06

-7.7

aspartokinase II in bifunctional enxyme: aspartokinase II; homoserine dehydrogenase II

lysC

Amino acid transport and metabolism

sa_c1918s1640_a_at

SA1226*

1.78E-05

-21.5

1.78E-05

-4.3

aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASA DH)

asd

Amino acid transport and metabolism

sa_c1922s1644_a_at

SA1227*

2.75E-07

-27.3

2.75E-07

-5.2

dihydrodipicolinate synthase (DHDPS)

dapA

Amino acid transport and metabolism, Cell envelope biogenesis, outer membrane

sa_c1924s1648_a_at

SA1228*

1.17E-07

-31.4

1.17E-07

-5.1

dihydrodipicolinate reductase (DHPR)

dapB

Amino acid transport and metabolism

sa_c1928s1652_a_at

SA1229*

2.55E-07

-23.5

2.55E-07

-4.4

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

dapD

Amino acid transport and metabolism

sa_c1936s1659_a_at

SA1231

8.94E-08

-18.5

8.94E-08

-3.0

Ala_racemase, Alanine racemase

Cell envelope biogenesis, outer membrane

sa_c3202s2750_a_at

SA1544

2.74E-05

-15.8

2.74E-05

-3.8

serine-pyruvate aminotransferase; alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase)

Amino acid transport and metabolism

sa_c3603s3083_a_at

SA1659

7.54E-06

-2.4

7.54E-06

-3.5

parvulin-like PPIase precursor (Peptidyl-prolyl cis-trans isomerase plp) (Rotamase plp)

prsA

Posttranslational modification, protein turnover, chaperones

sa_c10591s11046_s_at

SA1814

1.99E-05

-3.3

1.99E-05

-2.9

succinyl-diaminopimelate desuccinylase (dapE)

Amino acid transport and metabolism

sa_c5023s4322_at

SA2082

6.38E-07

-3.5

6.38E-07

-5.5

urease gamma chain (urea amidohydrolase)

ureA

Amino acid transport and metabolism

sa_c5029s4326_a_at

SA2083

2.01E-06

-4.3

2.01E-06

-7.6

URE2_staxy urease beta subunit

ureB

Amino acid transport and metabolism

sa_c5031s4330_a_at

SA2084

1.84E-07

-3.0

1.84E-07

-4.4

urease alpha chain (urea amidohydrolase)

ureC

Amino acid transport and metabolism

sa_c5035s4334_at

SA2085

1.71E-05

-2.9

1.71E-05

-4.2

urease accessory protein UreE

ureE

Posttranslational modification, protein turnover, chaperones

sa_c5039s4340_a_at

SA2086

1.40E-05

-2.3

1.40E-05

-3.8

urease accessory protein UreF

ureF

Posttranslational modification, protein turnover, chaperones

sa_c9293s8136_a_at

SA2088

0.000118

-2.2

0.000118

-2.8

urease accessory protein UreD

ureD

Posttranslational modification, protein turnover, chaperones

sa_c5303s4583_a_at

SA2149

1.28E-07

-35.8

1.28E-07

-64.9

probable peptide ABC transporter ATP-binding ABC transporter protein

hypothetical protein

sa_c5307s4587_at

SA2150

9.33E-07

-36.5

9.33E-07

-69.0

ABC-type transporter, permease component

hypothetical protein

sa_c5777s5020_a_at

SA2235

2.82E-05

-5.1

2.82E-05

-3.5

putative ABC transporter; osmoprotectant-binding protein,

opuCC

Cell envelope biogenesis, outer membrane

sa_c6435s5604_a_at

SA2409

0.000134

-4.6

0.000134

-2.2

anaerobic ribonucleoside-triphosphate reductase activating protein

Posttranslational modification, protein turnover, chaperones


Group V: Downregulation (20 min) – No change (60 min) 35 genes


sa_c37s34_a_at

SA0010

2.44E-06

-4.7

branched-chain amino acid permease

Amino acid transport and metabolism

sa_c4055s3432_a_at

SA0201

0.00111

-2.3

RGD-containing lipoprotein

rlp

Amino acid transport and metabolism

sa_c7055s6165_a_at

SA0331

0.000236

-3.0

probable lipoprotein

Inorganic ion transport and metabolism

sa_c7100s6210_a_at

SA0344

2.80E-06

-15.2

methyltetrahydropteroyltriglutamate – homocysteine methyltransferase (vitamin-B12-independent methionine synthase isozyme)

metE

Amino acid transport and metabolism

sa_c5418s4689_a_at

SA0420

7.55E-05

-2.8

probable amino acid ABC transporter, ATP-binding protein (abc)

Inorganic ion transport and metabolism

sa_c7374s6406_a_at

SA0421

6.63E-07

-3.3

putative amino acid ABC transporter, permease protein, glutamine transport system

Inorganic ion transport and metabolism

sa_c5431s4700_a_at

SA0769

2.32E-06

-5.4

probable amino acid ABC transporter, ATP-binding protein

Inorganic ion transport and metabolism

sa_c8512s7471_a_at

SA0770

1.42E-05

-6.3

permease protein of ABC transporter system

Inorganic ion transport and metabolism

sa_c8518s7475_a_at

SA0771

5.12E-06

-7.5

probable D-methionine-binding lipoprotein metQ precursor (Outer membrane lipoprotein1)

Inorganic ion transport and metabolism

sa_c350s191_a_at

SA0849

8.12E-05

-2.1

oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-2)

Amino acid transport and metabolism

sa_c352s195_a_at

SA0850

0.000757

-3.4

periplasmic oligopeptide-binding protein of oligopeptide ABC transporter

Amino acid transport and metabolism

sa_c1820s1547_a_at

SA1200

0.00698

-2.1

para-aminobenzoate synthetase glutamine amidotransferase component II

Amino acid transport and metabolism, Coenzyme metabolism

sa_c1828s1551_a_at

SA1201

0.000803

-2.8

pir|AE0653 anthranilate synthase component II,

trpD

Amino acid transport and metabolism

sa_c1832s1558_a_at

SA1202

0.00239

-4.5

anthranilate synthase; indole-glycerol phosphate synthase;

trpC

Amino acid transport and metabolism

sa_c1836s1562_at

SA1203

0.00279

-4.3

indole-3-glycerolphosphate synthetase

trpF

Amino acid transport and metabolism

sa_c1840s1566_a_at

SA1204

0.000663

-3.6

tryptophan synthase beta chain; tryptophan synthase (beta subunit)

trpB

Amino acid transport and metabolism

sa_c1844s1570_a_at

SA1205

5.52E-05

-2.6

tryptophan synthase alpha chain; tryptophan synthase

trpA

Amino acid transport and metabolism

sa_c1866s1587_a_at

SA1211

0.000158

-2.3

ATP-binding ABC transporter protein

opp-2F

Amino acid transport and metabolism

sa_c4209s3561_a_at

SA1858

0.000144

-6.2

dihydroxy-acid dehydratase (DAD)

ilvD

Amino acid transport and metabolism, Coenzyme metabolism

sa_c4213s3565_a_at

SA1859

0.000431

-8.0

acetolactate synthase isozyme III large subunit (AHAS-III)

ilvB

Amino acid transport and metabolism, Coenzyme metabolism

sa_c9931s8627_a_at

SA1861

0.000255

-10.3

ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase)

ilvC

Amino acid transport and metabolism, Coenzyme metabolism

sa_c4223s3575_a_at

SA1862

4.06E-05

-9.8

2-isopropylmalate synthase

leuA

Amino acid transport and metabolism

sa_c4225s3576_a_at

SA1863

5.85E-05

-11.0

3-isopropylmalate dehydrogenase

leuB

Energy production and conversion, Amino acid transportand metabolism

sa_c4229s3580_a_at

SA1864

1.39E-05

-13.2

3-isopropylmalate dehydratase large subunit

leuC

Amino acid transport and metabolism

sa_c4239s3588_a_at

SA1865

6.09E-05

-13.1

3-isopropylmalate dehydratase small subunit

leuD

Amino acid transport and metabolism

sa_c4243s3594_a_at

SA1866

1.58E-05

-7.3

threonine dehydratase biosynthetic (Threonine deaminase) (TD)

ilvA

Amino acid transport and metabolism

sa_c9447s10370cs_s_at

SA2464*

0.00225

-10.5

histidine biosynthesis bifunctional protein

hisI

Amino acid transport and metabolism

sa_c6696s10090cs_s_at

SA2465*

0.00199

-10.6

Imidazole glycerol phosphate synthase subunit hisF

hisF

Amino acid transport and metabolism

sa_c6706s5846_a_at

SA2466*

0.00148

-14.5

phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Amino acid transport and metabolism

sa_c6708s5850_a_at

SA2467

0.00213

-14.6

Imidazole glycerol phosphate synthase subunit hisH

hisH

Amino acid transport and metabolism

sa_c6714s5853_a_at

SA2468*

0.00639

-13.6

Imidazoleglycerol-phosphate dehydratase (IGPD)

hisB

Amino acid transport and metabolism

sa_c6718s5857_a_at

SA2469

0.00106

-19.8

histidinol-phosphate aminotransferase

Amino acid transport and metabolism

sa_c6728s5871_a_at

SA2472

0.0059

-14.5

ATPphosphoribosyltransferase regulatory subunit

hisZ

Amino acid transport and metabolism

sa_c6740s5882_a_at

SA2475

0.000217

-6.6

ABC transporter membrane-spanning permease – unknown substrate

Inorganic ion transport and metabolism

sa_c5397s4673_a_at

SA2476

0.000459

-7.6

putative ABC transporter; ATP-binding protein; possible cobalt transport system

Inorganic ion transport and metabolism


Group VI: No change (20 min) – Downregulation (60 min) 19 genes


sa_c2346s1974_a_at

SA0144

4.02E-05

-3.1

capsular polysaccharide synthesis enzyme Cap5A

capA

Cell envelope biogenesis, outer membrane

sa_c2385s1987_a_at

SA0145

4.55E-06

-2.9

capsular polysaccharide synthesis enzyme Cap5B

capB

Cell division and chromosome partitioning

sa_c2399s1991_a_at

SA0146

0.00055

-2.6

capsular polysaccharide synthesis enzyme Cap8C

capC

Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism

sa_c2413s1997_a_at

SA0147

0.0001

-2.6

capsular polysaccharide synthesis enzyme Cap5D

capD

Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism

sa_c9546s8318_a_at

SA0148

9.77E-05

-2.8

putative UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase)

capE

Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism

sa_c2479s2056_a_at

SA0149

2.40E-06

-3.1

capsular polysaccharide synthesis enzyme Cap5F

capF

Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism

sa_c2516s2092_a_at

SA0150

5.92E-05

-2.4

UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc-2-epimerase)

capG

Cell envelope biogenesis, outer membrane

sa_c10086s8810_a_at

SA0151

0.00025

-2.8

chloramphenicol acetyltransferase (Xenobiotic acetyltransferase) (XAT)

capH

General function prediction only

sa_c10087s8814_a_at

SA0152

0.00017

-2.7

capsular polysaccharide synthesis enzyme Cap5I

capI

Cell envelope biogenesis, outer membrane

sa_c10089s8822_a_at

SA0154

0.00103

-2.1

capsular polysaccharide synthesis enzyme Cap5K

capK

Cell envelope biogenesis, outer membrane

sa_c898s698_a_at

SA0977

0.00044

-2.7

29-kDa cell surface protein

isdA

Cell envelope biogenesis, outer membrane

sa_c906s704_a_at

SA0978

0.00538

-2.2

hypothetical protein SirD

isdC

Cell envelope biogenesis, outer membrane

sa_c3380s9339_a_at

SA1586

1.41E-05

-2.4

6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase)

ribH

Coenzyme metabolism

sa_c3387s2918_a_at

SA1587

6.15E-06

-2.8

probable riboflavin biosynthesis bifunctional protein

ribA

Coenzyme metabolism

sa_c3391s2919_a_at

SA1588

3.10E-06

-2.7

riboflavin synthase alpha chain

ribB

Coenzyme metabolism

sa_c3395s2925_a_at

SA1589

5.10E-07

-3.0

riboflavin specific deaminase

ribD

Coenzyme metabolism

sa_c4369s3721_at

SA1894

0.000661

-2.3

thiamine-phosphate pyrophosphorylase

thiE

Coenzyme metabolism

sa_c4373s3725_a_at

SA1895

3.05E-05

-2.5

hydroxyethylthiazole kinase

thiM

Coenzyme metabolism

sa_c4379s3726_a_at

SA1896

0.000137

-2.8

bifunctional enzyme: hydroxy-phosphomethylpyrimidine kinase

thiD

Coenzyme metabolism


Group VII: Downregulation (20 min) – Upregulation (60 min) 3 genes


sa_c9442s8255_a_at

SA2459*

0.0016

-2.5

0.0016

2.5

intercellular adhesion protein IcaA

icaA

Cell envelope biogenesis, outer membrane

sa_c6677s5830_a_at

SA2460*

0.0136

-2.0

0.0136

4.7

IcaD

icaD

Cell envelope biogenesis, outer membrane

sa_c6681s9106_a_at

SA2461*

3.83E-06

-2.1

3.83E-06

3.4

intercellular adhesion protein IcaB

icaB

Cell envelope biogenesis, outer membrane


* Genes were validated by real-time PCR.

Jang et al. BMC Genomics 2008 9:411   doi:10.1186/1471-2164-9-411

Open Data