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Open Access Highly Accessed Database

Fungal cytochrome P450 database

Jongsun Park123, Seungmin Lee1, Jaeyoung Choi12, Kyohun Ahn1, Bongsoo Park4, Jaejin Park12, Seogchan Kang4* and Yong-Hwan Lee1235*

Author Affiliations

1 Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea

2 Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea

3 Center for Fungal Genetic Resource, Seoul National University, Seoul 151-921, Korea

4 Department of Plant Pathology, The Pennsylvania State University, University Park, PA 16802, USA

5 Center for Agricultural Biomaterials, Seoul National University, Seoul 151-921, Korea

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BMC Genomics 2008, 9:402  doi:10.1186/1471-2164-9-402

Published: 28 August 2008

Abstract

Background

Cytochrome P450 enzymes play critical roles in fungal biology and ecology. To support studies on the roles and evolution of cytochrome P450 enzymes in fungi based on rapidly accumulating genome sequences from diverse fungal species, an efficient bioinformatics platform specialized for this super family of proteins is highly desirable.

Results

The Fungal Cytochrome P450 Database (FCPD) archives genes encoding P450s in the genomes of 66 fungal and 4 oomycete species (4,538 in total) and supports analyses of their sequences, chromosomal distribution pattern, and evolutionary histories and relationships. The archived P450s were classified into 16 classes based on InterPro terms and clustered into 141 groups using tribe-MCL. The proportion of P450s in the total proteome and class distribution in individual species exhibited certain taxon-specific characteristics.

Conclusion

The FCPD will facilitate systematic identification and multifaceted analyses of P450s at multiple taxon levels via the web. All data and functions are available at the web site http://p450.riceblast.snu.ac.kr/ webcite.