Table 9

Differentially expressed genes encoding proteins with Zn-finger motifs in artesunate-treated cells

Gene ID

Description

Zn-finger

ART 90 min

ART 3 h

HS

CQ


PFE1245w

hypothetical protein, conserved

Zinc finger C-x8-C-x5-C-x3-H type (PF00642)

1,28

0,91

+

+

PF14_0236

hypothetical protein

Zinc finger C-x8-C-x5-C-x3-H type (PF00642)

0,89

+

PFC0680w

hypothetical protein, conserved

Zinc finger C-x8-C-x5-C-x3-H type (PF00642)

1,55

+

PF10_0186

hypothetical protein

Zinc finger C-x8-C-x5-C-x3-H type (PF00642)

0,98

MAL13P1.122

hypothetical protein, conserved

PHD-finger (IPR001965)

0,81

PF14_0197

hypothetical protein

DNL zinc finger (PF05180)

0,87

PFI0470w

FHA domain protein, putative

C3HC4 type (RING finger) (PF00097)

0,89

1,05

PF10_0046

hypothetical protein

C3HC4 type (RING finger) (PF00097)

1,17

PFF0165c

hypothetical protein, conserved

C3HC4 type (RING finger) (PF00097)

0,94

PFL0440c

hypothetical protein, conserved

C3HC4 type (RING finger) (PF00097)

0,95

PFB0140w

hypothetical protein

DHHC zinc finger domain (PF01529)

-0,91

MAL13P1.76

TFIIH basal transcription factor subunit

TFIIH C1-like domain (PF07975)

-0,83


Gene ID: identifier as found in PlasmoDB.

Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.

HS and CQ columns: over (+) expression.

Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].

Genes containing Zn-motifs were defined as genes fitting the following Zn-finger HMM profiles: B-box zinc finger (PF00643), C3HC zinc finger-like (PF07967), C3HC4 type (RING finger) (PF00097), CHY zinc finger (PF05495), CSL zinc finger (PF05207), CW-type Zinc Finger (PF07496), DHHC zinc finger domain (PF01529), DNL zinc finger (PF05180), FYVE zinc finger (PF01363), HIT zinc finger (PF04438), MIZ/SP-RING zinc finger (PF02891), MYND finger (PF01753), PHD-finger (PF00628), Putative zinc finger motif, C2HC5-type (PF06221), Sec23/Sec24 zinc finger (PF04810), SWIM zinc finger (PF04434), TFIIH C1-like domain (PF07975), Tim10/DDP family zinc finger (PF02953), U1 zinc finger (PF06220), Zinc finger C-x8-C-x5-C-x3-H type (and similar)(PF00642), Zinc finger found in FPG and IleRS (PF06827), Zinc finger, C2H2 type (PF00096), Zinc finger, ZZ type (PF00569), ZN-finger, Zn-finger in Ran binding protein and others (PF00641), Zn-finger in ubiquitin-hydrolases and other protein (PF02148), ZPR1 zinc-finger domain (PF03367), AN1-like Zinc finger (PF01428), C2H2 and C2HC zinc fingers (SSF57667), PHD-finger (IPR001965).

Natalang et al. BMC Genomics 2008 9:388   doi:10.1186/1471-2164-9-388

Open Data