Table 3

Differentially expressed transport associated genes in artesunate-treated cells

Gene ID

Description

ART 90 min

ART 3 h

HS

CQ


PF07_0121

NMD3 protein, putative

0,85

PFB0435c

amino acid transporter, putative

0,89

PFE1455w

sugar transporter, putative

0,92

+

PFE1150w

multidrug resistance protein, Pfmdr1

1,10

PF11_0141

UDP-galactose transporter, putative

-0,86

-0,82

-

PFC0725c

formate-nitrate transporter, putative

-1,16

-

MAL8P1.13

integral membrane protein, conserved/folate-Biopterin transporter

-1,13

MAL13P1.206

Na+ -dependent Pi transporter, sodium-dependent phosphate transporter PfPiT

-0,90

PF13_0252

nucleoside transporter 1 PfNT1/PfENT1

-1,32

PFL0170w

Transporter, major facilitator superfamily

-0,86

-

PFE0410w

triose or hexose phosphate/phosphate translocator, putative

-0,88

-

PF13_0227

vacuolar ATP synthase subunit D, putative

-0,92

PF11_0412

Vacuolar ATP synthase subunit F, putative

-0,81

-

PF13_0130

vacuolar ATP synthase subunit G, putative

-0,82

-

PFE0965c

vacuolar ATP synthetase, subunit C putative

-0,85


Gene ID: identifier as found in PlasmoDB.

Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.

HS and CQ columns: over (+) or under (-) expression.

Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].

Genes involved in transport were selected from the pathway maps of Ginsburg [16].

Natalang et al. BMC Genomics 2008 9:388   doi:10.1186/1471-2164-9-388

Open Data